CAS 93129-94-3|Tacalcitol monohydrate

Introduction：Basic information about CAS 93129-94-3|Tacalcitol monohydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tacalcitol monohydrate BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Tacalcitol monohydrate
CAS Number	93129-94-3	Molecular Weight	434.652
Density	/	Boiling Point	/
Molecular Formula	C₂₇H₄₆O₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, hydrate , (1R,3S,5Z)
Synonym	More Synonyms

Tacalcitol monohydrate BiologicalActivity

Description	Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium.IC50 value:Target: Tacalcitol modulates immunological and inflammatory processes. Tacalcitol induces nerve growth factor production in epidermal keratinocytes.
Related Catalog	Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Others
References	[1]. Koyano K, Saitoh Y, Oshida J, Takimoto-Kamimura M.Dimer and superstructure of the active form of a vitamin D3; 1 alpha,24(R)dihydroxy-vitamin D3 monohydrate, C27O3H44.H2O.Chem Pharm Bull (Tokyo). 2001 Mar;49(3):305-11. [2]. Fukuoka et alTacalcitol, an active vitamin D3, induces nerve growth factor in human epidermal keratinocytes. Skin Pharmacol.Appl.Skin Physiol. (2001) 14 226. [3]. Rostowska-Nadolska et al Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblasts. Adv.Med.Sci. (2010) 55 86.

Description

Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium.IC50 value:Target: Tacalcitol modulates immunological and inflammatory processes. Tacalcitol induces nerve growth factor production in epidermal keratinocytes.

Related Catalog

Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Others

References

[1]. Koyano K, Saitoh Y, Oshida J, Takimoto-Kamimura M.Dimer and superstructure of the active form of a vitamin D3; 1 alpha,24(R)dihydroxy-vitamin D3 monohydrate, C27O3H44.H2O.Chem Pharm Bull (Tokyo). 2001 Mar;49(3):305-11.

[2]. Fukuoka et alTacalcitol, an active vitamin D3, induces nerve growth factor in human epidermal keratinocytes. Skin Pharmacol.Appl.Skin Physiol. (2001) 14 226.

[3]. Rostowska-Nadolska et al Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblasts. Adv.Med.Sci. (2010) 55 86.

Chemical & Physical Properties

Molecular Formula	C₂₇H₄₆O₄
Molecular Weight	434.652
Exact Mass	434.339600
PSA	69.92000
LogP	5.49630
InChIKey	UCLYOJXQGOXQKJ-OIIUTJHZSA-N
SMILES	C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)CCC(O)C(C)C)CC(O)CC1O.O
Storage condition	2-8℃

Synonyms

9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,24-TRIOL,MONOHYDRATE, (1A,3B,5Z,7E,24R)-

(1S,3R,5Z,7E,24R)-9,10-Secocholesta-5,7,10-triene-1,3,24-triol hydrate (1:1)

1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-, hydrate (1:1)

Tacalcitol monohydrate

9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, monohydrate, (1α,3β,5Z,7E,24R)-

1α,24(R)-Dihydroxycholecalciferol monohydrate

Tacalcitol (monohydrate)

(1R,3S)-5-[2-[(1R,3AR,7AS)-1-[(2R,5S)-5-HYDROXY-6-METHYL-HEPTAN-2-YL]-7A-METHYL-2,3,3A,5,6,7-HEXAHYD

1α,24(R)-Dihydroxy-vitamin D3 monohydrate

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