CAS 226700-79-4|fosamprenavir

Introduction：Basic information about CAS 226700-79-4|fosamprenavir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Namefosamprenavir
CAS Number226700-79-4Molecular Weight585.61
Density1.4±0.1 g/cm3Boiling Point/
Molecular FormulaC25H36N3O9PSMelting Point/
MSDS/Flash Point/

Names

Namefosamprenavir
SynonymMore Synonyms

fosamprenavir BiologicalActivity

DescriptionFosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].
Related CatalogSignaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection
Target

HIV[1]

References

[1]. Falcoz C, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98.

Chemical & Physical Properties

Density1.4±0.1 g/cm3
Molecular FormulaC25H36N3O9PS
Molecular Weight585.61
Exact Mass585.190979
PSA195.91000
LogP3.36
Index of Refraction1.612
InChIKeyMLBVMOWEQCZNCC-OEMFJLHTSA-N
SMILESCC(C)CN(CC(OP(=O)(O)O)C(Cc1ccccc1)NC(=O)OC1CCOC1)S(=O)(=O)c1ccc(N)cc1
Storage condition2-8℃

Synonyms

fosamprenavir
(3S)-Tetrahydro-3-furanyl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](isobutyl)amino}-1-phenyl-3-(phosphonooxy)-2-butanyl]carbamate
Lexiva
Amprenavir phosphate
((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic Acid C-((3S)-Tetrahydro-3-furanyl) Ester
((3S)Oxolan-3-yloxy)-N-((1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-benzyl-2-(phosphonooxy)propyl)carboxamide
(3S)-Tetrahydrofuran-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](isobutyl)amino}-1-phenyl-3-(phosphonooxy)butan-2-yl]carbamate
GW 433 908
Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, (3S)-tetrahydro-3-furanyl ester
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