CAS 41100-52-1|memantine hydrochloride
| Common Name | memantine hydrochloride | ||
|---|---|---|---|
| CAS Number | 41100-52-1 | Molecular Weight | 215.763 |
| Density | / | Boiling Point | 239.8ºC at 760 mmHg |
| Molecular Formula | C12H22ClN | Melting Point | 292 °C |
| MSDS | USA | Flash Point | 92.3ºC |
Names
| Name | memantine hydrochloride |
|---|---|
| Synonym | More Synonyms |
memantine hydrochloride BiologicalActivity
| Description | Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease |
| References | [1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34. [2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36. [3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46. |
Chemical & Physical Properties
| Boiling Point | 239.8ºC at 760 mmHg |
|---|---|
| Melting Point | 292 °C |
| Molecular Formula | C12H22ClN |
| Molecular Weight | 215.763 |
| Flash Point | 92.3ºC |
| Exact Mass | 215.144073 |
| PSA | 26.02000 |
| LogP | 4.19640 |
| InChIKey | LDDHMLJTFXJGPI-UHFFFAOYSA-N |
| SMILES | CC12CC3CC(C)(C1)CC(N)(C3)C2.Cl |
| Storage condition | -20°C Freezer |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2921300090 |
Customs
| HS Code | 2921300090 |
|---|---|
| Summary | 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| 1,3-Dimethyl-5-aminoadamantane hydrochloride |
| Axura |
| 3,5-Dimethyl-1-adamantanamine Hydrochloride |
| 3,5-Dimethyladamantan-1-amine hydrochloride (1:1) |
| MFCD00214336 |
| 3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid |
| Ebixza |
| 1-Amino-3,5-dimethyladamantane Hydrochloride |
| Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1) |
| 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride |
| Memantine Hydrochloride |
| 3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate |
| Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride |
| Ebixia |
| SUN Y7017 |
| 3,5-Dimethyl-1-adamantanamine hydrochloride (1:1) |
| EINECS 255-219-6 |
| tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride |
| 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1) |
| MemantineHCl |
| 3,5-Dimethyladamantan-1-amine hydrochloride |
| Memantine HCL |
| Akatinol |
| Menantine Hydrochloride |
| Memantine (hydrochloride) |
