CAS 94361-06-5|Cyproconazole

Introduction：Basic information about CAS 94361-06-5|Cyproconazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Cyproconazole BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles22
7. Synonyms

Common Name	Cyproconazole
CAS Number	94361-06-5	Molecular Weight	291.77600
Density	1.32	Boiling Point	>250ºC
Molecular Formula	C₁₅H₁₈ClN₃O	Melting Point	106.2-106.9ºC
MSDS	ChineseUSA	Flash Point	>100 °C
Symbol	GHS07, GHS08, GHS09	Signal Word	Warning

Names

Name	cyproconazole
Synonym	More Synonyms

Cyproconazole BiologicalActivity

Description	Cyproconazole is a triazole fungicide that is used agriculturally for protection of crops against a wide variety of fungal pathogens.In vitro: Cyproconazole has been shown to cause a dose dependent inhibition of progesterone production in human placental cells in vitro. cyproconazole exhibited the lowest capacity to increase CYP1A1 and were not able to activate the AhR in the transactivation assay. [1]In vivo: Cyproconazole, a triazole fungicide, causes hepatocellular adenomas and carcinomas in CD-1 mice at dose levels of 100 and 200 ppm. In wild-type mice, 200 ppm cyproconazole caused liver hypertrophy, increased liver weight and cell proliferation, single-cell necrosis and fat vacuolation. [2]
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Others
References	[1]. Rieke S et al. Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a humanplacental cell line. Int J Environ Res Public Health. 2014 Sep 17;11(9):9660-79. [2]. Peffer RC et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 2007 Sep;99(1):315-25.

Description

Cyproconazole is a triazole fungicide that is used agriculturally for protection of crops against a wide variety of fungal pathogens.In vitro: Cyproconazole has been shown to cause a dose dependent inhibition of progesterone production in human placental cells in vitro. cyproconazole exhibited the lowest capacity to increase CYP1A1 and were not able to activate the AhR in the transactivation assay. [1]In vivo: Cyproconazole, a triazole fungicide, causes hepatocellular adenomas and carcinomas in CD-1 mice at dose levels of 100 and 200 ppm. In wild-type mice, 200 ppm cyproconazole caused liver hypertrophy, increased liver weight and cell proliferation, single-cell necrosis and fat vacuolation. [2]

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Others

References

[1]. Rieke S et al. Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a humanplacental cell line. Int J Environ Res Public Health. 2014 Sep 17;11(9):9660-79.

[2]. Peffer RC et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 2007 Sep;99(1):315-25.

Chemical & Physical Properties

Density	1.32
Boiling Point	>250ºC
Melting Point	106.2-106.9ºC
Molecular Formula	C₁₅H₁₈ClN₃O
Molecular Weight	291.77600
Flash Point	>100 °C
Exact Mass	291.11400
PSA	50.94000
LogP	2.86540
InChIKey	UFNOUKDBUJZYDE-UHFFFAOYSA-N
SMILES	CC(C1CC1)C(O)(Cn1cncn1)c1ccc(Cl)cc1
Storage condition	2-8C

Safety Information

Symbol	GHS07, GHS08, GHS09
Signal Word	Warning
Hazard Statements	H302-H361-H410
Precautionary Statements	P273-P281-P501
Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S36/37-S60-S61
RIDADR	UN3077 9/PG 3
RTECS	XZ4803250
Hazard Class	9.0
HS Code	2933990015

Customs

HS Code	2933990015
Summary	2933990015 3-((1h-1,2,4-triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles22

Is the amphibian X. laevis WEC a good alternative method to rodent WEC teratogenicity assay? The example of the three triazole derivative fungicides Triadimefon, Tebuconazole, Cyproconazole.

Reprod. Toxicol. 32(2) , 220-6, (2011)

The aim of the present work is the assessment of teratogenic effects of three triazole-derived fungicides (Triadimefon, FON, Tebuconazole, TEBU, Cyproconazole, CYPRO) on rat and Xenopus laevis embryos...

Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.

Toxicol. Lett. 221(1) , 47-56, (2013)

To clarify the dose-response relationship between constitutive androstane receptor (CAR) activity and induction of cytochrome P450 2B (CYP2B) expression and hypertrophy by triazole fungicides in mouse...

[Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates].

Rev. Soc. Bras. Med. Trop. 40(2) , 209-11, (2007)

The activity of azole fungicides for agronomical use (epoxiconazole, difenoconazole and cyproconazole) was evaluated in comparison with the therapeutic antifungal agent fluconazole, on 23 environmenta...

Synonyms

1H-1,2,4-Triazole-1-ethanol,a-(4-chlorophenyl)-a-(1-cyclopropylethyl)-

Cyproconazol

2RS,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

2-(4-CHLOROPHENYL)-3-CYCLOPROPYL-1-(1,2,4-TRIAZOL-1-YL)BUTAN-2-OL

2-(4-Chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

rac-(2R,3RS)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

(2RS,3RS

α-(4-chlorophenyl)-α-(1-cyclopropylethyl)-1H-1,2,4-triazole-1-ethanol

MFCD01678672

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