CAS 768-94-5|Adamantan-1-amine
Introduction：Basic information about CAS 768-94-5|Adamantan-1-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Adamantan-1-amine | ||
|---|---|---|---|
| CAS Number | 768-94-5 | Molecular Weight | 151.249 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 225.7±8.0 °C at 760 mmHg |
| Molecular Formula | C10H17N | Melting Point | 206-208 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 96.0±9.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | amantadine |
|---|---|
| Synonym | More Synonyms |
Adamantan-1-amine BiologicalActivity
| Description | Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
| References | [1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 225.7±8.0 °C at 760 mmHg |
| Melting Point | 206-208 °C(lit.) |
| Molecular Formula | C10H17N |
| Molecular Weight | 151.249 |
| Flash Point | 96.0±9.7 °C |
| Exact Mass | 151.136093 |
| PSA | 26.02000 |
| LogP | 2.22 |
| Vapour Pressure | 0.1±0.4 mmHg at 25°C |
| Index of Refraction | 1.558 |
| InChIKey | DKNWSYNQZKUICI-UHFFFAOYSA-N |
| SMILES | NC12CC3CC(CC(C3)C1)C2 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 223 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- >316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | YD1925000 |
Articles68
More Articles| Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II. Arch. Virol. 160(5) , 1163-70, (2015) Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses... | |
| CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes. Colloids Surf. B Biointerfaces 105 , 31-6, (2013) This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped... | |
| A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport. Aquat. Toxicol. 159 , 127-37, (2015) The gill is the principle site of xenobiotic transfer to and from the aqueous environment. To replace, refine or reduce (3Rs) the large numbers of fish used in in vivo uptake studies an effective in v... |
Synonyms
| 1-Adamantanamine |
| EXP 105-1 |
| 1-Amantadine |
| (3s,5s,7s)-adamantan-1-amine |
| adamantan-1-amine |
| tricyclo[3.3.1.13,7]decan-1-amine |
| Symmetrel |
| TCMDC-125869 |
| Tricyclo[3.3.1.1]decan-1-amine |
| SYMADINE |
| 1-Adamantylamine |
| Mydantane |
| (3s,5s,7s)-1-Adamantanamine |
| adamantylamine |
| EINECS 212-201-2 |
| Amantadine |
| 1-Aminotricyclo[3.3.1.13,7]decane |
| Adamantanamine |
| 1-aminoadamantine |
| adamantyl amine |
| tricyclo[3.3.1.1]décan-1-amine |
| Trivaline |
| Pk-merz |
| Amazolon |
| 1-Aminodiamantane |
| 1-adamantaneamine |
| 1-aminoadamantane |
| MFCD00074732 |
| Aminoadamantane |
| Mantadine |
| Tricyclo[3.3.1.1^3,7]decan-1-amine |
| Virofral |
| 1-aminoadamantan |
| Tricyclo[3.3.1.1]decan-1-amin |
| Virasol |
| Amantadine Base |
| Influenol |
| 1-Adamantanamine (8CI) |
| Adamantamine |
