CAS 99-93-4|4-Hydroxyacetophenone
Introduction：Basic information about CAS 99-93-4|4-Hydroxyacetophenone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Hydroxyacetophenone | ||
|---|---|---|---|
| CAS Number | 99-93-4 | Molecular Weight | 136.148 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 313.0±0.0 °C at 760 mmHg |
| Molecular Formula | C8H8O2 | Melting Point | 132-135 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 121.2±12.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4'-hydroxyacetophenone |
|---|---|
| Synonym | More Synonyms |
4-Hydroxyacetophenone BiologicalActivity
| Description | 4-Hydroxyacetophenone (P-hydroxyacetophenone) is a key hepatoprotective and choleretic compound in Artemisia capillaris and A. morrisonensis, also has an anti-hepatitis B virus effect and anti-inflammatory effect[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Ching-Wen C, et al. p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models. J Nat Med. 2017 Apr;71(2):422-432. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 313.0±0.0 °C at 760 mmHg |
| Melting Point | 132-135 °C(lit.) |
| Molecular Formula | C8H8O2 |
| Molecular Weight | 136.148 |
| Flash Point | 121.2±12.4 °C |
| Exact Mass | 136.052429 |
| PSA | 37.30000 |
| LogP | 1.42 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.552 |
| InChIKey | TXFPEBPIARQUIG-UHFFFAOYSA-N |
| SMILES | CC(=O)c1ccc(O)cc1 |
| Storage condition | Refrigerator |
| Water Solubility | 10 g/L (22 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36/37-S37/39-S24/25-S22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | PC4959775 |
| HS Code | 2914509090 |
Customs
| HS Code | 2914501900 |
|---|---|
| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 1-(4-Hydroxyphenyl)ethan-1-one |
| Piceol |
| 1-Acetyl-4-hydroxybenzene |
| 4'-Hydroxyacetophenone |
| QR DV1 |
| EINECS 202-802-8 |
| 4-Acetylphenol |
| 4-Hydroxyacetophenone |
| p-Acetylphenol |
| Phenol, p-acetyl- |
| Acetophenone, p-hydroxy- |
| p-Hydroxyphenyl methyl ketone |
| (4-Hydroxyphenyl)ethan-1-one |
| 1-(4-Hydroxyphenyl)ethanone |
| Ethanone, 1-(4-hydroxyphenyl)- |
| 4′-Hydroxyacetophenone |
| MFCD00002355 |
