CAS 123-08-0|4-hydroxybenzaldehyde
Introduction：Basic information about CAS 123-08-0|4-hydroxybenzaldehyde, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-hydroxybenzaldehyde | ||
|---|---|---|---|
| CAS Number | 123-08-0 | Molecular Weight | 122.121 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 246.6±13.0 °C at 760 mmHg |
| Molecular Formula | C7H6O2 | Melting Point | 112-116 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 101.3±12.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4-hydroxybenzaldehyde |
|---|---|
| Synonym | More Synonyms |
4-hydroxybenzaldehyde BiologicalActivity
| Description | p-Hydroxybenzaldehyde is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorNatural Products >>Acids and AldehydesResearch Areas >>Neurological Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | p-Hydroxybenzaldehyde (4-hydroxybenzaldehyde) is a one of the major components in Dendrocalamus asper bamboo shoots, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations. p-Hydroxybenzaldehyde (101.7 μM) significantly reduces the GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes[1]. |
| References | [1]. Zhang J, et al. The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor. Malays J Med Sci. 2017 Mar;24(2):94-99. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 246.6±13.0 °C at 760 mmHg |
| Melting Point | 112-116 °C(lit.) |
| Molecular Formula | C7H6O2 |
| Molecular Weight | 122.121 |
| Flash Point | 101.3±12.4 °C |
| Exact Mass | 122.036781 |
| PSA | 37.30000 |
| LogP | 1.39 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.618 |
| InChIKey | RGHHSNMVTDWUBI-UHFFFAOYSA-N |
| SMILES | O=Cc1ccc(O)cc1 |
| Storage condition | Store at 2-8°C |
| Water Solubility | 13 g/L (30 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3980 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - tremor Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 1 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,17,1988
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | CU6475000 |
| Packaging Group | I; II; III |
| HS Code | 2912210000 |
Customs
| HS Code | 2912499000 |
|---|---|
| Summary | 2912499000. other aldehyde-ethers, aldehyde-phenols and aldehydes with other oxygen function. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| p-Hydroxybenzaldehyde |
| MFCD00006939 |
| 4-Hydroxy benzaldehyde |
| 4-Hydroxybenzaldehyde |
| EINECS 204-599-1 |
| Bisoprolol Impurity 15 |
