CAS 548-04-9|Hypericin

Introduction：Basic information about CAS 548-04-9|Hypericin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Hypericin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles71
7. Synonyms

Common Name	Hypericin
CAS Number	548-04-9	Molecular Weight	504.443
Density	1.9±0.1 g/cm3	Boiling Point	930.1±65.0 °C at 760 mmHg
Molecular Formula	C₃₀H₁₆O₈	Melting Point	299-301°C
MSDS	ChineseUSA	Flash Point	530.1±30.8 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	hypericin
Synonym	More Synonyms

Hypericin BiologicalActivity

Description	Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.
Related Catalog	Signaling Pathways >>Others >>OthersNatural Products >>OthersResearch Areas >>Others
References	[1]. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41. [2]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62. [3]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.

Description

Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.

Related Catalog

Signaling Pathways >>Others >>OthersNatural Products >>OthersResearch Areas >>Others

References

[1]. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41.

[2]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62.

[3]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.

Chemical & Physical Properties

Density	1.9±0.1 g/cm3
Boiling Point	930.1±65.0 °C at 760 mmHg
Melting Point	299-301°C
Molecular Formula	C₃₀H₁₆O₈
Molecular Weight	504.443
Flash Point	530.1±30.8 °C
Exact Mass	504.084503
PSA	155.52000
LogP	8.39
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	2.131
InChIKey	YDOIFHVUBCIUHF-UHFFFAOYSA-N
SMILES	Cc1cc(=O)c2c(O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(O)c7c(=O)cc(C)c8c1c2c(c34)c(c65)c78
Storage condition	Store at +4°C
Water Solubility	1 M NaOH: 10 mg/mL

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H317
Precautionary Statements	P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S22-S36
RIDADR	2811
WGK Germany	3
HS Code	2914700090

Customs

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles71

Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium).

Fitoterapia 100 , 95-109, (2015)

In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Is...

Alterations in dysadherin expression and F-actin reorganization: a possible mechanism of hypericin-mediated photodynamic therapy in colon adenocarcinoma cells.

Cytotechnology 67(2) , 311-30, (2015)

Dysadherin is a recently found anti-adhesion molecule, therefore detection and down regulation of its expression is promising in cancer treatment. The up-regulation of dysadherin contributes to colon ...

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Drug Metab. Dispos. 36 , 1385-405, (2008)

We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...

Synonyms

Phenanthro[1,10,9,8-opqra]perylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-

EINECS 208-941-0

1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione

CYCLOSAN

Hypericin

MYCOPORPHYRIN

HYPERICUM RED

VIMRxyn

4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone

MYCOPOPHYRIN

CYCLO-WERROL

MFCD02100619

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