Introduction：Basic information about CAS 2586-96-1|Liensinine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Liensinine |
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| CAS Number | 2586-96-1 | Molecular Weight | 610.739 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 722.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C37H42N2O6 | Melting Point | 95-99ºC |
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| MSDS | / | Flash Point | 390.4±32.9 °C |
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Names
| Name | Liensinine |
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| Synonym | More Synonyms |
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Liensinine BiologicalActivity
| Description | Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>Mitophagy |
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| References | [1]. Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 722.0±60.0 °C at 760 mmHg |
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| Melting Point | 95-99ºC |
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| Molecular Formula | C37H42N2O6 |
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| Molecular Weight | 610.739 |
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| Flash Point | 390.4±32.9 °C |
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| Exact Mass | 610.304260 |
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| PSA | 83.86000 |
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| LogP | 4.84 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.618 |
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| InChIKey | XCUCMLUTCAKSOZ-FIRIVFDPSA-N |
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| SMILES | COc1cc2c(cc1OC)C(Cc1ccc(O)c(Oc3cc4c(cc3OC)CCN(C)C4Cc3ccc(O)cc3)c1)N(C)CC2 |
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Safety Information
Synonyms
| 4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-{[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl]oxy}phenol |
| 4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-{[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}phenol |
| Hiensinine |
| Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]- |
