CAS 27208-80-6|Polydatin

Introduction：Basic information about CAS 27208-80-6|Polydatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Polydatin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Polydatin
CAS Number	27208-80-6	Molecular Weight	390.384
Density	1.5±0.1 g/cm3	Boiling Point	707.7±60.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₂O₈	Melting Point	223-226ºC (dec.)
MSDS	Chinese	Flash Point	381.8±32.9 °C

Names

Name	trans-piceid
Synonym	More Synonyms

Polydatin BiologicalActivity

Description	Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models.
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Inflammation/ImmunologyNatural Products >>Phenols
Target	NF-κB, Autophagy
In Vitro	Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells[1].
In Vivo	Polydatin could significantly increase the activity of SOD and the heart rate, attenuate myocardial pathological damage, decrease MDA content, slightly increase arterial pressure and GSH-Px activity, reduce intervals of QRS, QT and ST, and lower FFA content[2].
Cell Assay	The effect of polydatin on mMEC viability is evaluated with an MTT assay. mMECs are incubated in the presence or absence of various concentrations of polydatin (25, 50 and 100 μg/mL) and DEX (100 μg/mL) for 24 h. Next, 20 μL of MTT (5 mg/mL) is added to each well and incubated for 4 h. After the supernatants are removed and the formazan is dis¬solved with 150 μL of DMSO in each well, the optical density (OD) value is measured at 570 nm on a microplate reader[3].
Animal Admin	Rats: Rats are divided into six groups by random assignment and treated as follows: in normal group and polydatin control group: rats are administrated with CMC-Na and polydatin (200 μmol/kg) by gavage respectively, and given normal saline (NS) by tail intravenous (iv) injection with the same volume; in DOX group: rats are injected with DOX by cauda vein for 4 weeks (3 mg/kg per week), the cumulative dosage is 12 mg/kg similar to that in the research of Chang et al[2]. Mice: Polydatin is dissolved in dimethyl sulfoxide (DMSO) and diluted in Dulbecco’s modified Eagle’s medium (DMEM). Sixty adult female postpartum and lactating BALB/c mice (6–8 weeks old, weighing 35–40 g) are obtained. Control group (CG): The mice are treated with 100 μL of PBS as a vehicle control. Polydatin groups: 24h after S aureus infection, the mouse model of S aureus mastitis is intraperitoneally administered polydatin at 15, 30 and 45 mg/kg[3].
References	[1]. Cheng Y, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusioninjury. Brain Res. 2006 Sep 19;1110(1):193-200. [2]. Wang HL, et al. Synergistic effects of Polydatin and Vitamin C in Inhibiting Cardiotoxicity induced by Doxorubicin in rats. Fundam Clin Pharmacol. 2016 Nov 28. [Epub ahead of print] [3]. Jiang KF, et al. Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway. Acta Pharmacol Sin. 2016 Nov 28. [Epub ahead of print]

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	707.7±60.0 °C at 760 mmHg
Melting Point	223-226ºC (dec.)
Molecular Formula	C₂₀H₂₂O₈
Molecular Weight	390.384
Flash Point	381.8±32.9 °C
Exact Mass	390.131470
PSA	139.84000
LogP	1.00
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.737
InChIKey	HSTZMXCBWJGKHG-CUYWLFDKSA-N
SMILES	OCC1OC(Oc2cc(O)cc(C=Cc3ccc(O)cc3)c2)C(O)C(O)C1O

Safety Information

Safety Phrases	S22-S24/25
WGK Germany	3

Synonyms

Resveratrol 3-O-glucoside

3-Hydroxy-5-[2-(4-hydroxyphenyl)ethenyl]phenyl-b-D-glucopyranoside

β-D-Glucopyranoside, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl

trans-polydatin

3-Hydroxy-5-(p-hydroxystyryl)phenyl Glucoside

β-D-Glucopyranoside, 3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl

MFCD00210592

3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl β-D-glucopyranoside

Piceid

trans-Piceid

Resveratrol 3-Glucoside

Polydotin peceid

Pieceid

Plydatin

4',5-Dihydroxystilben-3-yl β-D-Glucopyranoside

Resveratrol-3-b-mono-D-glucoside

3,4',5-Trihydroxystilbene-3-b-glucoside

3-Hydroxy-5-[(E)-2-(4-hydroxyphenyl)vinyl]phenyl β-D-glucopyranoside

RESVERATROL GLUCOSIDE

Polydatin

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