Introduction：Basic information about CAS 41059-79-4|Timosaponin A3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Timosaponin A3 |
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| CAS Number | 41059-79-4 | Molecular Weight | 740.918 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 862.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C39H64O13 | Melting Point | / |
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| MSDS | / | Flash Point | 475.6±34.3 °C |
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Names
| Name | Timosaponin A-III |
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| Synonym | More Synonyms |
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Timosaponin A3 BiologicalActivity
| Description | Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>AChENatural Products >>OthersResearch Areas >>Neurological Disease |
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| Target | IC50: 35.4 μM (AChE)[1]. |
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| In Vitro | Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM[1]. Timosaponin AIII is identified as a major selective cytotoxic activity in BN108, and its selective cytotoxic activity involves inhibition of mTOR, induction of ER stress and protective autophagy[2]. |
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| In Vivo | Of the tested steroidal saponins, Timosaponin AIII (TA3) most potently improves memory deficits. Timosaponin AIII increases the scopolamine-induced reduction in step-through latency by 17% (10 mg/kg), 28% (20 mg/kg), and 43% (40 mg/kg). During the acquisition trial, no differences in latent time are observed. Timosaponin AIII (20, 40 mg/kg, p.o.) potently inhibits this reduction of acetylcholine in scopolamine-treated mouse brain. The inhibitory effect of Timosaponin AIII is comparable to that of tacrine, which is used as a positive control[1]. |
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| Animal Admin | Mice[1] Male ICR mice weighing 28-30 g are used. For the acquisition trial, mice are initially placed in the illuminated compartment and the door between the two compartments is opened 10 s later. Each group contains ten mice. One hour or 5 h before the acquisition trial, mice receive each test agent (e.g., Timosaponin AIII 10, 20 or 40 mg/kg, p.o. ). One hour before the acquisition trial, mice receive tacrine (10 mg/kg, p.o.) as a positive control. Memory impairment is induced by scopolamine treatment (1 mg/kg, i.p.) 0.5 h or 4.5 h after the administration of test agents, tacrine, or 10% Tween 80 solution. Control animals are administered 10% Tween 80 solution alone. Twenty-four hours after the acquisition trial, the mice are again placed in the illuminated compartment for retention trials. The time taken for a mouse to enter the dark compartment after the door opened is measured as the latency time in both acquisition and retention trials, with a maximum of 300 s[1]. |
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| References | [1]. Lee B, et al. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacol Biochem Behav. 2009 Aug;93(2):121-7. [2]. King FW, et al. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One. 2009 Sep 30;4(9):e7283. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 862.8±65.0 °C at 760 mmHg |
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| Molecular Formula | C39H64O13 |
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| Molecular Weight | 740.918 |
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| Flash Point | 475.6±34.3 °C |
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| Exact Mass | 740.434692 |
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| PSA | 196.99000 |
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| LogP | 3.94 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.606 |
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| InChIKey | MMTWXUQMLQGAPC-ARGJBTHBSA-N |
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| SMILES | CC1CCC2(OC1)OC1CC3C4CCC5CC(OC6OC(CO)C(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C |
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Safety Information
Synonyms
| Timosaponin A3 |
| XilingsaponinA |
| (3β,5β)-Spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside |
| Filiferin B |
| β-D-Galactopyranoside, (3β,5β)-spirostan-3-yl 2-O-β-D-glucopyranosyl- |
| Timosaponina- |
