CAS 81-27-6|Sennoside A
| Common Name | Sennoside A | ||
|---|---|---|---|
| CAS Number | 81-27-6 | Molecular Weight | 862.739 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 1144.8±65.0 °C at 760 mmHg |
| Molecular Formula | C42H38O20 | Melting Point | 200-240ºC |
| MSDS | ChineseUSA | Flash Point | 348.6±27.8 °C |
Names
| Name | sennoside A |
|---|---|
| Synonym | More Synonyms |
Sennoside A BiologicalActivity
| Description | Sennoside A is an anthraquinone glycoside, found in large quantities in leaves and pods of Senna (Cassia angustifolia)[1]. Sennoside A is a HIV-1 inhibitor effective on HIV-1 replication[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
| References | [1]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [2]. Esposito F, et al. Sennoside A, derived from the traditional chinese medicine plant Rheum L., is a new dual HIV-1 inhibitor effective on HIV-1 replication. Phytomedicine. 2016 Nov 15;23(12):1383-1391. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 1144.8±65.0 °C at 760 mmHg |
| Melting Point | 200-240ºC |
| Molecular Formula | C42H38O20 |
| Molecular Weight | 862.739 |
| Flash Point | 348.6±27.8 °C |
| Exact Mass | 862.195618 |
| PSA | 347.96000 |
| LogP | 1.88 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.763 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R22 |
| Safety Phrases | 22-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles25
More Articles| The influence of rhein 8-O-β-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice. Biol. Pharm. Bull. 35(12) , 2204-8, (2012) Rhubarb is one of the most well-known herbal medicines that constitute daiokanzoto (DKT), which is clinically effective for constipation. Sennoside A is transformed into an active metabolite, rheinant... | |
| The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice. Biol. Pharm. Bull. 34(9) , 1438-42, (2011) Daiokanzoto (DKT), a Kampo medicine that includes the combination of two crude drugs (rhubarb and glycyrrhiza), is clinically effective for constipation. The aim of this study is to clarify the influe... | |
| Effects of optimized-SopungSunkiwon on memory impairment and enhancement. Neurosci. Lett. 491(2) , 93-8, (2011) Optimized-SopungSunkiwon (OSS) is a multi-herbal formula that contains six medicinal herbs from SopungSunkiwon, a traditional medicine used for neurodegenerative disorders. In this study, we investiga... |
Synonyms
| Tomato juice |
| SennosideA |
| PURSENNID |
| Sennoside A |
| Sennoside B |
| EINECS 201-339-9 |
| MFCD00151527 |
| Glysennid |
| GLYSENNIDE |
| SENNOSIDA |
| PURSENNIDE |
| SENNOSIDE |
| [9,9'-Bianthracene]-2,2'-dicarboxylic acid, 5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (9R,9'S)- |
| (9R,9'S)-5,5'-Bis(β-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid |
| (9R,9'S)-4,4'-Dihydroxy-10,10'-dioxo-5,5'-bis{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid |
