CAS 175135-47-4|O4I1

Introduction：Basic information about CAS 175135-47-4|O4I1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. O4I1 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	O4I1
CAS Number	175135-47-4	Molecular Weight	253.296
Density	1.1±0.1 g/cm3	Boiling Point	424.5±30.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₅NO₂	Melting Point	140ºC
MSDS	/	Flash Point	154.8±17.8 °C

Names

Name	2-[4-[(4-methoxyphenyl)methoxy]phenyl]acetonitrile
Synonym	More Synonyms

O4I1 BiologicalActivity

Description	O4I1 is as a potent Oct3/4 inducer.Target: Oct3/4O4I1 enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. O4I1 activates Oct3/4 at the transcriptional and translational levels in diverse human cell lines. O4I1 promotes Oct3/4 expression in untransfected HEK293 cells quantified by qRT-PCR after 72 h of treatment. O4I1 is sufficient to enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 h of treatment, respectively.
Related Catalog	Signaling Pathways >>Stem Cell/Wnt >>Oct3/4Research Areas >>Others
References	[1]. Cheng X, et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-4983. [2]. Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103.

Description

O4I1 is as a potent Oct3/4 inducer.Target: Oct3/4O4I1 enhances Oct3/4 gene expression, increases Oct3/4 protein levels, and promotes Oct3/4 mediated transcriptional activation. O4I1 activates Oct3/4 at the transcriptional and translational levels in diverse human cell lines. O4I1 promotes Oct3/4 expression in untransfected HEK293 cells quantified by qRT-PCR after 72 h of treatment. O4I1 is sufficient to enhance Oct3/4 overexpression 2-fold and 3-fold after 48 and 72 h of treatment, respectively.

Related Catalog

Signaling Pathways >>Stem Cell/Wnt >>Oct3/4Research Areas >>Others

References

[1]. Cheng X, et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-4983.

[2]. Mrowka, et al. Method for activating OCT4 for induction of pluripotent stem cell formation. From PCT Int. Appl. (2014), WO 2014000814 A1 20140103.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	424.5±30.0 °C at 760 mmHg
Melting Point	140ºC
Molecular Formula	C₁₆H₁₅NO₂
Molecular Weight	253.296
Flash Point	154.8±17.8 °C
Exact Mass	253.110275
PSA	42.25000
LogP	2.93
Appearance of Characters	light yellow solid
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.570
InChIKey	QJEJLARVLKHYFW-UHFFFAOYSA-N
SMILES	COc1ccc(COc2ccc(CC#N)cc2)cc1
Storage condition	-20℃

Safety Information

Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36/37
HS Code	2926909090

Customs

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Synonyms

2-[4-[(4-Methoxyphenyl)methoxy]phenyl]-acetonitrile

4-(4-methoxybenzyloxy)benzylnitrile

Benzeneacetonitrile, 4-[(4-methoxyphenyl)methoxy]-

{4-[(4-Methoxybenzyl)oxy]phenyl}acetonitrile

O4I1

2-(4-((4-Methoxybenzyl)oxy)phenyl)acetonitrile

2-(4-[(4-METHOXYBENZYL)OXY]PHENYL)ACETONITRILE

O4I-1

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