Introduction：Basic information about CAS 28230-32-2|HOOBT, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HOOBT |
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| CAS Number | 28230-32-2 | Molecular Weight | 163.133 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 348.7±25.0 °C at 760 mmHg |
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| Molecular Formula | C7H5N3O2 | Melting Point | 184-189°C |
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| MSDS | Chinese | Flash Point | 164.7±23.2 °C |
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| Symbol |
GHS02, GHS07, GHS08 | Signal Word | Danger |
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Names
| Name | 3-hydroxy-1,2,3-benzotriazin-4-one |
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| Synonym | More Synonyms |
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HOOBT BiologicalActivity
| Description | HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATResearch Areas >>CancerSignaling Pathways >>Anti-infection >>HIVResearch Areas >>InfectionSignaling Pathways >>JAK/STAT Signaling >>STAT |
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| Target | STAT5 |
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| In Vitro | HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells)[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10)[1]. HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro[1]. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 348.7±25.0 °C at 760 mmHg |
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| Melting Point | 184-189°C |
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| Molecular Formula | C7H5N3O2 |
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| Molecular Weight | 163.133 |
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| Flash Point | 164.7±23.2 °C |
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| Exact Mass | 163.038177 |
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| PSA | 68.01000 |
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| LogP | 0.43 |
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| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
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| Index of Refraction | 1.739 |
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| InChIKey | HJBLUNHMOKFZQX-UHFFFAOYSA-N |
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| SMILES | O=c1c2ccccc2nnn1O |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS02, GHS07, GHS08 |
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| Signal Word | Danger |
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| Hazard Statements | H226-H312 + H332-H315-H319-H335-H360D |
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| Precautionary Statements | P201-P261-P280-P305 + P351 + P338-P308 + P313 |
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| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | Xi:Irritant |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S53-S26-S35-S36/37-S45-S37/39 |
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| RIDADR | UN 3379 3/PG 1 |
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| WGK Germany | 3 |
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| Hazard Class | 3.0 |
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| HS Code | 2933699090 |
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Customs
| HS Code | 2933699090 |
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| Summary | 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0% |
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Synonyms
| HOOBT |
| EINECS 248-916-1 |
| 3-hydroxybenzo[d]1,2,3-triazin-4-one |
| 3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one |
| 1,2,3-Benzotriazin-4(3H)-one, 3-hydroxy- |
| DHBT |
| oxohydroxybenzotriazole |
| 4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine |
| 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one |
| 3-Hydroxy-4-ketobenzotriazine |
| 3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one |
| 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine |
| 1,2,3-Benzotriazin-4(3H)-one,3-hydroxy |
| MFCD00042803 |
| 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine |
| 3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine |
