Introduction：Basic information about CAS 105102-22-5|Mometasone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mometasone |
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| CAS Number | 105102-22-5 | Molecular Weight | 521.42900 |
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| Density | 1.35g/cm3 | Boiling Point | 586.6ºC at 760mmHg |
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| Molecular Formula | C27H30Cl2O6 | Melting Point | 220ºC (decomposes) |
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| MSDS | / | Flash Point | 308.5ºC |
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Names
| Name | mometasone |
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| Synonym | More Synonyms |
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Mometasone BiologicalActivity
| Description | Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2]. |
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| Related Catalog | Research Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Glucocorticoid Receptor |
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| In Vivo | Mometasone (0.1-3 mg/kg; intranasally) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested of 3 mg/kg, and dose-dependently inhibits the allergen-induced increase in Penh in a mouse model of allergic lung inflammation[3]. |
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| References | [1]. Veien NK, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999 May;140(5):882-6. [2]. Lazarus SC, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019. [3]. Wyss D, et al. Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol. 2007 Sep;152(1):83-90. |
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Chemical & Physical Properties
| Density | 1.35g/cm3 |
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| Boiling Point | 586.6ºC at 760mmHg |
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| Melting Point | 220ºC (decomposes) |
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| Molecular Formula | C27H30Cl2O6 |
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| Molecular Weight | 521.42900 |
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| Flash Point | 308.5ºC |
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| Exact Mass | 520.14200 |
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| PSA | 93.81000 |
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| LogP | 4.86920 |
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| Vapour Pressure | 4.47E-18mmHg at 25°C |
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| Index of Refraction | 1.603 |
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| InChIKey | QLIIKPVHVRXHRI-CXSFZGCWSA-N |
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| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1(O)C(=O)CCl |
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Synonyms
| 9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione |
| MFCD02683426 |
| Pregna-1,4-diene-3,20-dione,9,21-dichloro-11,17-dihydroxy-16-methyl-,(11b,16a)-(9CI) |
| Mometasone |
| MOMETOSONE FUROATE |
