CAS 88150-47-4|Amlodipine maleate

Introduction：Basic information about CAS 88150-47-4|Amlodipine maleate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Amlodipine maleate BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Amlodipine maleate
CAS Number	88150-47-4	Molecular Weight	524.948
Density	/	Boiling Point	527.2ºC at 760 mmHg
Molecular Formula	C₂₄H₂₉ClN₂O₉	Melting Point	/
MSDS	/	Flash Point	272.6ºC

Names

Name	Amlodipine maleate
Synonym	More Synonyms

Amlodipine maleate BiologicalActivity

Description	Amlodipine maleate is a long-acting calcium channel blocker.Target: Calcium ChannelAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. From Wikipedia.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease
References	[1]. http://en.wikipedia.org/wiki/Amlodipine

Chemical & Physical Properties

Boiling Point	527.2ºC at 760 mmHg
Molecular Formula	C₂₄H₂₉ClN₂O₉
Molecular Weight	524.948
Flash Point	272.6ºC
Exact Mass	524.156128
PSA	174.48000
LogP	3.00720
InChIKey	TZNOWAJJWCGILX-BTJKTKAUSA-N
SMILES	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.O=C(O)C=CC(=O)O
Storage condition	2-8℃

Synonyms

3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (2Z)-2-butenedioate (1:1)

Amlodipine (±)-form Maleate

Norvasc

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate

3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (2Z)-but-2-enedioate (1:1)

AMLODIPINE MALEATE MM STANDARD

3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate (2Z)-2-butenedioate (1:1)

UNII:CQ27G2BZJM

2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester

AmlodipineMaleateC20H25C1N205.C4H404

(±)-2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester (Z)-2-Butenedioate (1:1)

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (z)-2-butenedioate

3-ethyl-5-methyl-(4-RS)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate

(3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate) maleate

3-Ethyl 5-Methyl (±)-2-((2-Aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate Maleate (1:1)

MFCD02259457

Amlodipine maleate

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