CAS 60200-06-8|Clorsulon
Introduction：Basic information about CAS 60200-06-8|Clorsulon, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Clorsulon | ||
|---|---|---|---|
| CAS Number | 60200-06-8 | Molecular Weight | 380.656 |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 651.7±65.0 °C at 760 mmHg |
| Molecular Formula | C8H8Cl3N3O4S2 | Melting Point | 194-203°C |
| MSDS | ChineseUSA | Flash Point | 348.0±34.3 °C |
Names
| Name | 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide |
|---|---|
| Synonym | More Synonyms |
Clorsulon BiologicalActivity
| Description | Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
| References | [1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7. [2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41. |
Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 651.7±65.0 °C at 760 mmHg |
| Melting Point | 194-203°C |
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.656 |
| Flash Point | 348.0±34.3 °C |
| Exact Mass | 378.902191 |
| PSA | 163.10000 |
| LogP | 1.04 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.665 |
| InChIKey | QOVTVIYTBRHADL-UHFFFAOYSA-N |
| SMILES | Nc1cc(C(Cl)=C(Cl)Cl)c(S(N)(=O)=O)cc1S(N)(=O)=O |
| Storage condition | 0-6°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 761 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BVJOA9 British Veterinary Journal. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.105- 1949- Volume(issue)/page/year: 133,211,1977
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | CZ9090000 |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles27
More Articles| Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon. Exp. Parasitol. 136 , 59-62, (2014) In the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anth... | |
| Intraspecific mitochondrial DNA variation of Fasciola hepatica eggs from sheep with different level of anthelmintic resistance. Parasitol. Res. 113(7) , 2733-41, (2014) In the current study, Fasciola hepatica strains of sheep with different degrees of resistance to anthelmintics were analyzed by sequencing the cytochrome C oxidase (COX1) and the NADH dehydrogenase (N... | |
| Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle. Vet. Parasitol. 162(3-4) , 278-84, (2009) The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nit... |
Synonyms
| Clorsulon [Spanish] |
| UNII-EG1ZDO6LRD |
| EINECS 262-100-2 |
| Clorsulonum [Latin] |
| 4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide |
| 4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide |
| Ivomec-F |
| 4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide |
| MFCD00072006 |
| Clorsulone [French] |
| Clorsulon |
| 1,3-Benzenedisulfonamide, 4-amino-6-(1,2,2-trichloroethenyl)- |
| Curatrem |
| 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide |
| 4-Amino-6-(trichlorethenyl)-1,3-benzoldisulfonamid |
| MK-401 |
| 4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide |
