CAS 94-67-7|salicylaldehyde, oxime
| Common Name | salicylaldehyde, oxime | ||
|---|---|---|---|
| CAS Number | 94-67-7 | Molecular Weight | 137.136 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 256.5±23.0 °C at 760 mmHg |
| Molecular Formula | C7H7NO2 | Melting Point | 59-61 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 146.9±11.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Salicylaldoxime |
|---|---|
| Synonym | More Synonyms |
salicylaldehyde, oxime BiologicalActivity
| Description | Salicylaldoxime is an organic compound, that has been used as a reagent for the gravimetric determination and separation of Cooper, Nickel, Palladium, Lead, Bismuth and Zine. The copper complex of Salicylaldoxime has anticancer activity[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| In Vitro | Salicylaldoxime (300 μM) completely inhibits the relaxation activity of topoisomerase II when it forms a complex with copper; also inhibits L1210 leukaemia cell proliferation[1]. |
| References | [1]. W Ligett and L Biefeld. Separation and Determination of Lead with Salicylaldoxime. Ind. Eng. Chem. Anal. Ed. 1941, 13, 11, 813-815. [2]. D. Jayaraju and Anand K. Kondapi. Anti-cancer copper salicylaldoxime complex inhibits topoisomerase II catalytic activity. Current Science. Vol. 81, No. 7 (10 October 2001), pp. 787-792 |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 256.5±23.0 °C at 760 mmHg |
| Melting Point | 59-61 °C(lit.) |
| Molecular Formula | C7H7NO2 |
| Molecular Weight | 137.136 |
| Flash Point | 146.9±11.9 °C |
| Exact Mass | 137.047684 |
| PSA | 52.82000 |
| LogP | 1.88 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.552 |
| InChIKey | ORIHZIZPTZTNCU-VMPITWQZSA-N |
| SMILES | ON=Cc1ccccc1O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,36,1953
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | VN5775000 |
Articles26
More Articles| Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes. Eur. J. Med. Chem. 46 , 2453-62, (2011) In a continuing effort to improve the subtype selectivity and agonist potency of estrogen receptor β (ERβ) ligands, we have designed and developed a thus far unexplored structural series obtained by m... | |
| Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J. Med. Chem. 52 , 858-67, (2009) The bioisosteric replacement of the phenol ring, a signature functional group of most estrogen receptor (ER) ligands, with a hydrogen-bonded pseudocyclic ring, led to the development of a novel class ... | |
| Linking [M(III)3] triangles with "double-headed" phenolic oximes. Dalton Trans. 41(29) , 8777-85, (2012) Strapping two salicylaldoxime units together with aliphatic α,Ω-aminomethyl links in the 3-position gives ligands which allow the assembly of the polynuclear complexes [Fe(7)O(2)(OH)(6)(H(2)L1)(3)(py)... |
Synonyms
| 2-hydroxybenzaldehyde oxime |
| salicylaldehyde, oxime |
| Saldox |
| Benzaldehyde, 2-hydroxy-, oxime |
| SALICYLALDEHYDE OXIME |
| Salicylaldehydoxime |
| 2-hydroxybenzaldoxime |
| SalicyladoximeGr |
| o-Hydroxybenzaldoxime |
| MFCD00002120 |
| o-hydroxybenzaldehyde oxime |
| EINECS 202-353-8 |
| 2-[(Hydroxyimino)methyl]phenol |
| Salicaldehyde oxime |
| 2-[(E)-(Hydroxyimino)methyl]phenol |
