Introduction：Basic information about CAS 66547-09-9|Ansamitocin P-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ansamitocin P-3 |
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| CAS Number | 66547-09-9 | Molecular Weight | 635.145 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 833.1±65.0 °C at 760 mmHg |
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| Molecular Formula | C32H43ClN2O9 | Melting Point | 182-185℃ |
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| MSDS | / | Flash Point | 457.7±34.3 °C |
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Names
| Name | Ansamitocin P-3' |
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| Synonym | More Synonyms |
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Ansamitocin P-3 BiologicalActivity
| Description | Ansamitocin P 3' exhibits antitumour activity, is an antibody drug conjugate cytotoxin. The more information please refer to Ansamitocin P-3 (HY-15739). |
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| Related Catalog | Signaling Pathways >>Antibody-drug Conjugate >>ADC CytotoxinResearch Areas >>Cancer |
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| References | [1]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 833.1±65.0 °C at 760 mmHg |
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| Melting Point | 182-185℃ |
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| Molecular Formula | C32H43ClN2O9 |
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| Molecular Weight | 635.145 |
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| Flash Point | 457.7±34.3 °C |
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| Exact Mass | 634.265686 |
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| PSA | 136.16000 |
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| LogP | 5.09 |
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| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
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| Index of Refraction | 1.583 |
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| InChIKey | WLKHTIAFMSHJLG-OQPBHURPSA-N |
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| SMILES | CCCC(=O)OC1CC(=O)N(C)c2cc(cc(OC)c2Cl)CC(C)=CC=CC(OC)C2(O)CC(OC(=O)N2)C(C)C2OC12C |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OQ2293000
- CHEMICAL NAME :
- Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)
- CAS REGISTRY NUMBER :
- 66547-09-9
- LAST UPDATED :
- 199401
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C32-H43-Cl-N2-O9
- MOLECULAR WEIGHT :
- 635.22
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 625 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-130495
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R20/22;R36/37/38 |
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| Safety Phrases | S26;S36 |
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| WGK Germany | 3 |
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| RTECS | OQ2293000 |
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Synonyms
| maytansinol 3-butyrate |
| Propanoic acid, 2-methyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,1
 4(26),16,18-pentaen-6-yl ester |
| C32H43ClN2O9 |
| Maytansinol butyrate |
| (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate |
| Ansamitocin P-3 |
| MFCD00274586 |
| Ansamitocin P 3' |
