CAS 122520-90-5|Tyrphostin 51

Introduction：Basic information about CAS 122520-90-5|Tyrphostin 51, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tyrphostin 51 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Tyrphostin 51
CAS Number	122520-90-5	Molecular Weight	268.228
Density	1.6±0.1 g/cm3	Boiling Point	788.2±60.0 °C at 760 mmHg
Molecular Formula	C₁₃H₈N₄O₃	Melting Point	278ºC
MSDS	Chinese	Flash Point	430.5±32.9 °C

Names

Name	tyrphostin a51
Synonym	More Synonyms

Tyrphostin 51 BiologicalActivity

Description	(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].
Related Catalog	Signaling Pathways >>JAK/STAT Signaling >>EGFRResearch Areas >>OthersSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR
References	[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230. [2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

Description

(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent protein tyrosine kinase (PTK) inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [3H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation[1][2].

Related Catalog

Signaling Pathways >>JAK/STAT Signaling >>EGFRResearch Areas >>OthersSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFR

References

[1]. Alexander A. et al. [3H]taurine andd-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases. Physiology-cell physiology. 1999, 1226-1230.

[2]. Yoon HK, et al. Differential effects of two protein tyrosine kinase inhibitors, tyrphostin and genistein, on human bone cell proliferation as compared with differentiation. Calcif Tissue Int. 1998 Sep;63(3):243-9.

Chemical & Physical Properties

Density	1.6±0.1 g/cm3
Boiling Point	788.2±60.0 °C at 760 mmHg
Melting Point	278ºC
Molecular Formula	C₁₃H₈N₄O₃
Molecular Weight	268.228
Flash Point	430.5±32.9 °C
Exact Mass	268.059631
PSA	158.08000
LogP	0.04
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.757
InChIKey	JKNOYWVMHPMBEL-UNXLUWIOSA-N
SMILES	N#CC(=Cc1cc(O)c(O)c(O)c1)C(N)=C(C#N)C#N
Storage condition	2-8°C

Safety Information

WGK Germany	3

Synonyms

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (3Z)-

ag 183

tyrphostin ag 183

1,3-Butadiene-1,1,3-tricarbonitrile, 2-amino-4-(3,4,5-trihydroxyphenyl)-, (Z)-

tyrphostin 51

(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile

(3Z)-2-Amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile

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