Introduction：Basic information about CAS 13345-50-1|PROSTAGLANDIN A2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PROSTAGLANDIN A2 |
|---|
| CAS Number | 13345-50-1 | Molecular Weight | 334.450 |
|---|
| Density | 1.1±0.1 g/cm3 | Boiling Point | 515.3±50.0 °C at 760 mmHg |
|---|
| Molecular Formula | C20H30O4 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 279.6±26.6 °C |
|---|
Names
| Name | prostaglandin A2 |
|---|
| Synonym | More Synonyms |
|---|
PROSTAGLANDIN A2 BiologicalActivity
| Description | Prostaglandin A2 (PGA2), a human endogenous metabolite of PGE2, is an antitumor agent. Prostaglandin A2 induces p53-dependent Apoptosis. Prostaglandin A2 also has antiviral activity[1][2][3]. |
|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerResearch Areas >>Infection |
|---|
| Target | Human Endogenous Metabolite |
|---|
| References | [1]. Lee SB, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A2. Biomolecules. 2020 Mar 24;10(3):492. [2]. Gorospe M, et al. Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Mol Cell Biol. 1996 Dec;16(12):6654-60. [3]. O'Brien WJ, et al. Assessment of antiviral activity, efficacy, and toxicity of prostaglandin A2 in a rabbit model of herpetic keratitis. Antimicrob Agents Chemother. 1996 Oct;40(10):2327-31. |
|---|
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|
| Boiling Point | 515.3±50.0 °C at 760 mmHg |
|---|
| Molecular Formula | C20H30O4 |
|---|
| Molecular Weight | 334.450 |
|---|
| Flash Point | 279.6±26.6 °C |
|---|
| Exact Mass | 334.214417 |
|---|
| PSA | 74.60000 |
|---|
| LogP | 3.25 |
|---|
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
|---|
| Index of Refraction | 1.555 |
|---|
| InChIKey | MYHXHCUNDDAEOZ-FOSBLDSVSA-N |
|---|
| SMILES | CCCCCC(O)C=CC1C=CC(=O)C1CC=CCCCC(=O)O |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UK8050000
- CHEMICAL NAME :
- Prostaglandin A(sup 2)
- CAS REGISTRY NUMBER :
- 13345-50-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C20-H30-O4
- MOLECULAR WEIGHT :
- 334.50
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 93 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,460,1973 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 1,191,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972 *** REVIEWS *** TOXICOLOGY REVIEW CSPEAX Cosmetics and Perfumery. (Oak Park, IL) V.88-90, 1973-75. For publisher information, see CTOIDG. Volume(issue)/page/year: 90(12),28,1975
|
Safety Information
| Hazard Codes | F: Flammable;Xi: Irritant; |
|---|
| Risk Phrases | R11 |
|---|
| Safety Phrases | S26 |
|---|
| RIDADR | UN 1231 3/PG 2 |
|---|
Synonyms
| PROSTAGLANDINS A2 |
| Prostaglandin A |
| Prosta-5,10,13-trien-1-oic acid, 15-hydroxy-9-oxo-, (5E,13E,15S)- |
| Prostaglandin A2 solution |
| (5E,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid |
| Prostaglandin A2 |
| MFCD00077859 |
| PGA2 |
| MEDULLIN |
