CAS 54197-31-8|IAA-94
| Common Name | IAA-94 | ||
|---|---|---|---|
| CAS Number | 54197-31-8 | Molecular Weight | 357.22800 |
| Density | 1.401g/cm3 | Boiling Point | 537.2ºC at 760 mmHg |
| Molecular Formula | C17H18Cl2O4 | Melting Point | / |
| MSDS | USA | Flash Point | 278.7ºC |
Names
| Name | 2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid |
|---|---|
| Synonym | More Synonyms |
IAA-94 BiologicalActivity
| Description | R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.IC50 value:Target: IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Chloride ChannelResearch Areas >>Others |
| References | [1]. Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98. [2]. Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72. [3]. Weber-Schürholz S, et al. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. J Biol Chem. 1993 Jan 5;268(1):547-51. |
Chemical & Physical Properties
| Density | 1.401g/cm3 |
|---|---|
| Boiling Point | 537.2ºC at 760 mmHg |
| Molecular Formula | C17H18Cl2O4 |
| Molecular Weight | 357.22800 |
| Flash Point | 278.7ºC |
| Exact Mass | 356.05800 |
| PSA | 63.60000 |
| LogP | 4.39210 |
| Index of Refraction | 1.597 |
| InChIKey | RNOJGTHBMJBOSP-KRWDZBQOSA-N |
| SMILES | CC1(C2CCCC2)Cc2cc(OCC(=O)O)c(Cl)c(Cl)c2C1=O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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Synonyms
| Indanyloxyacetic acid 94 (R(+)-Methylindazone |
| IAA-94 |
| Indanyloxyacetic acid |
| R(+)-IAA-94 |
