CAS 2898-76-2|Benzamil

Introduction：Basic information about CAS 2898-76-2|Benzamil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Benzamil BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Benzamil
CAS Number	2898-76-2	Molecular Weight	356.21100
Density	/	Boiling Point	/
Molecular Formula	C₁₃H₁₄ClN₇O	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
Synonym	More Synonyms

Benzamil BiologicalActivity

Description	Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium Channel
In Vitro	Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4].
In Vivo	Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].
References	[1]. Fischer KG, et al. Characterization of a Na(+)-Ca(2+) exchanger in podocytes. Nephrol Dial Transplant. 2002 Oct;17(10):1742-50. [2]. Wang X, et al. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response. Am J Physiol Renal Physiol. 2008 Jul;295(1):F272-82. [3]. Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85. [4]. Castañeda MS, et al. Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+channels. Neuropharmacology. 2019 Nov 1;158:107738. [5]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.

Chemical & Physical Properties

Molecular Formula	C₁₃H₁₄ClN₇O
Molecular Weight	356.21100
Exact Mass	355.07200
PSA	145.30000
LogP	3.59470
InChIKey	KXDROGADUISDGY-UHFFFAOYSA-N
SMILES	NC(=NCc1ccccc1)NC(=O)c1nc(Cl)c(N)nc1N
Storage condition	2-8°C

Safety Information

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	UN 2811
HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

GNF-Pf-192

Benzamil

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid benzylcarbamimidoyl-amide

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