Introduction：Basic information about CAS 370-81-0|oxalic bis(cyclohexylidenehydrazide), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2].
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Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In Vivo
Cuprizone (0.5 mg/100 mg of diet and water given ad lib; p.o.) produces severe status spongious in the CNS, most prominently in the brain stem and cerebellar white matter of mice[1].
References
[1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25.
[2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37.
Chemical & Physical Properties
Density
1.3±0.1 g/cm3
Melting Point
210-214 °C(lit.)
Molecular Formula
C14H22N4O2
Molecular Weight
278.350
Exact Mass
278.174286
PSA
82.92000
LogP
0.85
Index of Refraction
1.626
InChIKey
DSRJIHMZAQEUJV-UHFFFAOYSA-N
SMILES
O=C(NN=C1CCCCC1)C(=O)NN=C1CCCCC1
Storage condition
2-8°C
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
RO2520000
CHEMICAL NAME :
Oxalic acid, bis(cyclohexylidenehydrazide)
CAS REGISTRY NUMBER :
370-81-0
BEILSTEIN REFERENCE NO. :
2388004
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H22-N4-O2
MOLECULAR WEIGHT :
278.40
WISWESSER LINE NOTATION :
L6YTJ AUNMVVMNU- AL6YTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29400 mg/kg/7W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20160 mg/kg/8W-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
24 gm/kg
SEX/DURATION :
female 3-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
40 gm/kg
SEX/DURATION :
female 3-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
MUTATION DATA
TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
14 gm/kg/14D (Continuous)
REFERENCE :
EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967- Volume(issue)/page/year: 47,313,1974
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
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