CAS 481-39-0|Juglone
Introduction：Basic information about CAS 481-39-0|Juglone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Juglone | ||
|---|---|---|---|
| CAS Number | 481-39-0 | Molecular Weight | 174.153 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 385.8±42.0 °C at 760 mmHg |
| Molecular Formula | C10H6O3 | Melting Point | 161-163 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 201.3±24.4 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | juglone |
|---|---|
| Synonym | More Synonyms |
Juglone BiologicalActivity
| Description | Juglone is a yellow pigment found in black walnut (Juglans regia). Juglone also shows antimicrobial activity[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| References | [1]. J. Johnson Inbaraj, et al. Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes.Chem. Res. Toxicol. 2004, 17, 1, 55-62 |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 385.8±42.0 °C at 760 mmHg |
| Melting Point | 161-163 °C(lit.) |
| Molecular Formula | C10H6O3 |
| Molecular Weight | 174.153 |
| Flash Point | 201.3±24.4 °C |
| Exact Mass | 174.031693 |
| PSA | 54.37000 |
| LogP | 1.86 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.662 |
| InChIKey | KQPYUDDGWXQXHS-UHFFFAOYSA-N |
| SMILES | O=C1C=CC(=O)c2c(O)cccc21 |
| Storage condition | Refrigerator (+4°C) |
| Water Solubility | SOLUBLE IN HOT WATER |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 394 mg/kg/53W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 10 mg/kg
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,583,1967
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 10 mg/kg
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,583,1967
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H315-H319-H335-H400 |
| Precautionary Statements | P261-P273-P301 + P310-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R25;R36/37/38 |
| Safety Phrases | S22-S26-S36/37/39-S45-S37/39-S28A |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | QJ5775000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 2914690090 |
Customs
| HS Code | 2914690090 |
|---|---|
| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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| Determination of the Juglone Content of Juglans regia Leaves by GC/MS. Nat. Prod. Commun. 10 , 1239-42, (2015) The constituents of walnut (Juglans regia L.) leaves are represented by tannins, phenolics, and naphthoquinones, the characteristic compound being juglone. The content of juglone in the methanolic ext... |
Synonyms
| Nucin |
| Juglone |
| EINECS 207-567-5 |
| 5-Hydroxy-1,4-naphthalenedione |
| C.I. Natural Brown 7 |
| 5-hydroxynaphthalene-1,4-dione |
| Regianin |
| CI 75500 |
| 5-hydroxy-1,4-dihydronaphthalene-1,4-dione |
| 5-Hydroxy-1,4-naphthochinone |
| 1,4-Naphthalenedione, 5-hydroxy- |
| 5-HNQ |
| 5-Hydroxy-p-naphthoquinone |
| MFCD00001684 |
| 5-Hydroxy-1,4-naphthoquinone |
