CAS 60047-17-8|Linalool oxide

Introduction：Basic information about CAS 60047-17-8|Linalool oxide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Linalool oxide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles3
8. Synonyms

Common Name	Linalool oxide
CAS Number	60047-17-8	Molecular Weight	170.24900
Density	0.945 g/mL at 20 °C(lit.)	Boiling Point	188°C
Molecular Formula	C₁₀H₁₈O₂	Melting Point	/
MSDS	ChineseUSA	Flash Point	63°C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran
Synonym	More Synonyms

Linalool oxide BiologicalActivity

Description	Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity[1][2][3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Souto-Maior FN, et al. Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide. Pharm Biol. 2017 Dec;55(1):63-67. [2]. Souto-Maior FN, et al. Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models. Pharmacol Biochem Behav. 2011 Dec;100(2):259-63. [3]. Piesik D, et al. Mechanically-injured wheat plants release greater amounts of the secondary metabolites linalool and linalool oxide[J]. Journal of Plant Protection Research, 2006: 29-39-29-39.

Description

Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity[1][2][3].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Souto-Maior FN, et al. Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide. Pharm Biol. 2017 Dec;55(1):63-67.

[2]. Souto-Maior FN, et al. Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models. Pharmacol Biochem Behav. 2011 Dec;100(2):259-63.

[3]. Piesik D, et al. Mechanically-injured wheat plants release greater amounts of the secondary metabolites linalool and linalool oxide[J]. Journal of Plant Protection Research, 2006: 29-39-29-39.

Chemical & Physical Properties

Density	0.945 g/mL at 20 °C(lit.)
Boiling Point	188°C
Molecular Formula	C₁₀H₁₈O₂
Molecular Weight	170.24900
Flash Point	63°C
Exact Mass	170.13100
PSA	32.76000
LogP	1.88100
Index of Refraction	n20/D 1.452
InChIKey	BRHDDEIRQPDPMG-UHFFFAOYSA-N
SMILES	C=CC1(C)CCC(C(C)(C)O)O1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OI7782000

CHEMICAL NAME :: Linalool, epoxydihydro-, mixed isomers

CAS REGISTRY NUMBER :: 60047-17-8

BEILSTEIN REFERENCE NO. :: 0117527

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O2

MOLECULAR WEIGHT :: 170.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,863,1983 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,863,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,863,1983

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H314
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C
Risk Phrases	22-34
Safety Phrases	S23-S24/25
RIDADR	UN 1760 8 / PGIII
WGK Germany	2
RTECS	OI7782000
HS Code	2932190090

Customs

HS Code	2932190090
Summary	2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles3

Red:far-red light conditions affect the emission of volatile organic compounds from barley (Hordeum vulgare), leading to altered biomass allocation in neighbouring plants.

Ann. Bot. 115 , 961-70, (2015)

Volatile organic compounds (VOCs) play various roles in plant-plant interactions, and constitutively produced VOCs might act as a cue to sense neighbouring plants. Previous studies have shown that VOC...

Linalool oxide: generalist plant based lure for mosquito disease vectors.

Parasit. Vectors 8 , 581, (2015)

Lack of effective vaccines and therapeutics for important arboviral diseases such as Rift Valley fever (RVF) and dengue, necessitates continuous monitoring of vector populations for infections in them...

Behavioural response of female Culex pipiens pallens to common host plant volatiles and synthetic blends.

Parasit. Vectors 8 , 598, (2015)

Most mosquito species need to obtain sugar from host plants. Little is known about the chemical cues that Culex pipiens pallens use during their orientation to nectar host plants. In this study, we in...

Synonyms

EINECS 262-038-6

Linalool oxide

MFCD00053543

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