Introduction：Basic information about CAS 4880-88-0|Vinburnine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Vinburnine |
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| CAS Number | 4880-88-0 | Molecular Weight | 294.391 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 441.9±33.0 °C at 760 mmHg |
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| Molecular Formula | C19H22N2O | Melting Point | 174-177 °C(lit.) |
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| MSDS | / | Flash Point | 221.0±25.4 °C |
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Names
| Name | (-)-Eburnamonine |
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| Synonym | More Synonyms |
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Vinburnine BiologicalActivity
| Description | Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 441.9±33.0 °C at 760 mmHg |
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| Melting Point | 174-177 °C(lit.) |
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| Molecular Formula | C19H22N2O |
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| Molecular Weight | 294.391 |
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| Flash Point | 221.0±25.4 °C |
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| Exact Mass | 294.173218 |
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| PSA | 25.24000 |
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| LogP | 3.79 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.719 |
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| InChIKey | WYJAPUKIYAZSEM-MOPGFXCFSA-N |
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| SMILES | CCC12CCCN3CCc4c(n(c5ccccc45)C(=O)C1)C32 |
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| Storage condition | -20℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YY8575570
- CHEMICAL NAME :
- Vincamone
- CAS REGISTRY NUMBER :
- 4880-88-0
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H22-N2-O
- MOLECULAR WEIGHT :
- 294.43
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 265 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978
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Safety Information
| Safety Phrases | S22-S24/25 |
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| WGK Germany | 2 |
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| RTECS | YY8575570 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Eburnamenin-14-one, 14,15-dihydro-, (3α,16α)- |
| (13aS,13bS)-13a-éthyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphtyridin-12(5H)-one |
| (3α,16α)-14,15-Dihydroeburnamenin-14-one |
| 3a,16a-Eburnamonine |
| vinburnine |
| (-)-EBURNAMONINE |
| (3a,16a)-Eburnamenin-14(15H)-one |
| (13aS,13bS)-13a-Ethyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(5H)-one |
| Eburnamenin-14(15H)-one, (3α,16α)- |
| Vincamone |
| MFCD00064309 |
| 16-Oxoeburnane |
| (3a,16a)-Eburnamin-14(15H)-one |
| EINECS 225-490-5 |
| (13aS,13bS)-13a-Ethyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphthyridin-12(5H)-on |
| cis-Vincamone |
