Introduction：Basic information about CAS 521-52-8|Vulpic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Vulpic acid |
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| CAS Number | 521-52-8 | Molecular Weight | 322.31 |
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| Density | 1.375g/cm3 | Boiling Point | 568.8ºC at 760mmHg |
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| Molecular Formula | C19H14O5 | Melting Point | 146-148ºC |
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| MSDS | / | Flash Point | 210.2ºC |
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Names
| Name | Vulpinic Acid |
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| Synonym | More Synonyms |
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Vulpic acid BiologicalActivity
| Description | Vulpinic acid, a lichen metabolite, decreases H2O2-induced ROS production, oxidative stress and oxidative stress-related damages in human umbilical vein endothelial cells (HUVEC). Vulpinic acid is active against staphylococci, enterococci, and anaerobic bacteria.Vulpinic acid has the potential for atherosclerosis research[1][2]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. E Sahin, et al. Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress-related diseases, such as atherosclerosis. Hum Exp Toxicol. 2019 Jun;38(6):675-684. [2]. M Lauterwein, et al. In vitro activities of the lichen secondary metabolites vulpinic acid, (+)-usnic acid, and (-)-usnic acid against aerobic and anaerobic microorganisms. Antimicrob Agents Chemother. 1995 Nov;39(11):2541-3. |
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Chemical & Physical Properties
| Density | 1.375g/cm3 |
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| Boiling Point | 568.8ºC at 760mmHg |
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| Melting Point | 146-148ºC |
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| Molecular Formula | C19H14O5 |
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| Molecular Weight | 322.31 |
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| Flash Point | 210.2ºC |
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| Exact Mass | 322.08400 |
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| PSA | 72.83000 |
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| LogP | 3.09680 |
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| Index of Refraction | 1.656 |
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| Storage condition | -20°C Freezer |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- HF3500000
- CHEMICAL NAME :
- Delta(sup 2(5H),alpha)-furanacetic acid, 3-hydroxy-5-oxo-alpha,4-diphenyl-, methyl ester
- CAS REGISTRY NUMBER :
- 521-52-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H14-O5
- MOLECULAR WEIGHT :
- 322.33
- WISWESSER LINE NOTATION :
- T5VOYJ CUYR&VO1 DQ ER
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,30,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 2,109,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02804
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Safety Information
| Risk Phrases | 28 |
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| Safety Phrases | 1-22-45 |
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| RIDADR | UN 3172 |
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Synonyms
