CAS 29925-17-5|RO 20-1724
| Common Name | RO 20-1724 | ||
|---|---|---|---|
| CAS Number | 29925-17-5 | Molecular Weight | 278.35 |
| Density | 1.099 g/cm3 | Boiling Point | 483.8ºC at 760 mmHg |
| Molecular Formula | C15H22N2O3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 246.4ºC |
Names
| Name | 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one |
|---|---|
| Synonym | More Synonyms |
RO 20-1724 BiologicalActivity
| Description | Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Neurological Disease |
| Target | PDE4:1930 nM (Ki) |
| In Vivo | Ro 20-1724 (125, 250 and 500 μg/kg; i.p.; 21 days following first i.c.v. streptozotocin administration; 200-250 g adult (3-5 months old) male albino Wistar rats) significantly attenuated streptozotocin induced cognitive deficit and oxidative stress[2]. |
| References | [1]. Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854. [2]. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245. |
Chemical & Physical Properties
| Density | 1.099 g/cm3 |
|---|---|
| Boiling Point | 483.8ºC at 760 mmHg |
| Molecular Formula | C15H22N2O3 |
| Molecular Weight | 278.35 |
| Flash Point | 246.4ºC |
| Exact Mass | 278.16300 |
| PSA | 59.59000 |
| LogP | 2.75560 |
| Vapour Pressure | 1.62E-09mmHg at 25°C |
| Index of Refraction | 1.521 |
| InChIKey | PDMUULPVBYQBBK-UHFFFAOYSA-N |
| SMILES | CCCCOc1cc(CC2CNC(=O)N2)ccc1OC |
| Storage condition | Store at RT |
| Water Solubility | ethanol: 7 mg/mL |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles48
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Synonyms
| MFCD00077397 |
| 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone |
