CAS 481-06-1|Alpha-Santonin
Introduction：Basic information about CAS 481-06-1|Alpha-Santonin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alpha-Santonin | ||
|---|---|---|---|
| CAS Number | 481-06-1 | Molecular Weight | 246.30200 |
| Density | 1.18g/cm3 | Boiling Point | 423.4ºC at 760mmHg |
| Molecular Formula | C15H18O3 | Melting Point | 172-173 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 189.7ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | α-santonin |
|---|---|
| Synonym | More Synonyms |
Alpha-Santonin BiologicalActivity
| Description | Santonin is an active principle of the plant Artemisia cina, which is formely used to treat worms[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
| References | [1]. Sakipova Z, et al. Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation. PLoS One. 2017 Mar 16;12(3):e0173714. |
Chemical & Physical Properties
| Density | 1.18g/cm3 |
|---|---|
| Boiling Point | 423.4ºC at 760mmHg |
| Melting Point | 172-173 °C(lit.) |
| Molecular Formula | C15H18O3 |
| Molecular Weight | 246.30200 |
| Flash Point | 189.7ºC |
| Exact Mass | 246.12600 |
| PSA | 43.37000 |
| LogP | 2.41960 |
| Vapour Pressure | 2.24E-07mmHg at 25°C |
| Index of Refraction | -172.5 ° (C=2, CHCl3) |
| InChIKey | XJHDMGJURBVLLE-BOCCBSBMSA-N |
| SMILES | CC1=C2C3OC(=O)C(C)C3CCC2(C)C=CC1=O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,301,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,79S,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02213 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4536 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 7 (estimated)
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H310-H315-H319-H330-H335 |
| Precautionary Statements | P260-P280-P284-P302 + P350-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24/25 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | LE3150000 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
Articles27
More Articles| The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J. Neurosci. 33(1) , 201-13, (2013) Bitter taste is a basic taste modality, required to safeguard animals against consuming toxic substances. Bitter compounds are recognized by G-protein-coupled bitter taste receptors (TAS2Rs). The huma... | |
| Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones. Pharmacol. Biochem. Behav. 89(2) , 160-70, (2008) Here we report the prevention and reversal of cocaine-induced behaviors in planarian worms by parthenolide and two related cyclic sesquiterpene lactones (SL), costunolide and santonin. Using establish... | |
| Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report. Eur. J. Med. Chem. 60 , 365-75, (2013) α-Santonin derived new series of 1,2,3-triazoles synthesized through Azide-Alkyne Huisgen 1,3-dipolar cycloaddition reaction between substituted aryl azide and a propargylated α-desmotrosantonin were ... |
Synonyms
| Semenen |
| EINECS 207-560-7 |
| l-Santonin |
| A-SANTONIN |
| (3S,3aS,5aS,9bS)-3a,5,5a,9b-tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)-dione |
| MFCD00135865 |
| alpha-santonin |
| (3S,3aS,5aS,9bS)-3,5a,9-trimethyl-3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione |
| SANTONIN |
| SANTONIN,A |
| (3S,5aS,9bS)-3a,5,5a,9b-Tetrahydro-3,5a,9-trimethylnaphtho[1,2-b]furan-2,8(3H,4H)dione |
