CAS 60117-35-3|ANB-NOS
| Common Name | ANB-NOS | ||
|---|---|---|---|
| CAS Number | 60117-35-3 | Molecular Weight | 305.203 |
| Density | / | Boiling Point | / |
| Molecular Formula | C11H7N5O6 | Melting Point | 131-133ºC |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester |
|---|---|
| Synonym | More Synonyms |
ANB-NOS BiologicalActivity
| Description | ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
Chemical & Physical Properties
| Melting Point | 131-133ºC |
|---|---|
| Molecular Formula | C11H7N5O6 |
| Molecular Weight | 305.203 |
| Exact Mass | 305.039642 |
| PSA | 159.25000 |
| LogP | 0.53 |
| InChIKey | FUOJEDZPVVDXHI-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=Nc1ccc([N+](=O)[O-])c(C(=O)ON2C(=O)CCC2=O)c1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles12
More Articles| Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2. Biochemistry 16 , 5650-5654, (1977) Two novel heterobifunctional cross-linking reagents, which can be used to attach photoactivatable nitroaryl azides to primary amino groups of proteins, have been synthesized. The two compounds, N-5-az... | |
| Covalent binding of biological samples to solid supports for scanning probe microscopy in buffer solution. Biophys. J. 65(6) , 2437-46, (1993) Scanning force microscopy allows imaging of biological molecules in their native state in buffer solution. To this end samples have to be fixed to a flat solid support so that they cannot be displaced... | |
| [Structural characterization of the somatostatin receptors on rat cerebrocortical membranes]. Nihon Naibunpi Gakkai Zasshi 66(10) , 1108-16, (1990) We characterized structurally the receptors for somatostatin in rat cerebral cortex by affinity labeling with [125I-Tyr1] somatostatin. [125I-Tyr1] somatostatin was cross-linked to cerebrocortical mem... |
Synonyms
| 1-[(5-Azido-2-nitrobenzoyl)oxy]-2,5-pyrrolidinedione |
| 2,5-Pyrrolidinedione, 1-[(5-azido-2-nitrobenzoyl)oxy]- |
| 2,5-Pyrrolidinedione, 1-((5-azido-2-nitrobenzoyl)oxy)- |
| (2,5-dioxopyrrolidin-1-yl) 5-azido-2-nitrobenzoate |
