Introduction：Basic information about CAS 620-67-7|TRIHEPTANOIN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | TRIHEPTANOIN |
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| CAS Number | 620-67-7 | Molecular Weight | 428.603 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 470.0±12.0 °C at 760 mmHg |
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| Molecular Formula | C24H44O6 | Melting Point | / |
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| MSDS | / | Flash Point | 195.5±19.6 °C |
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Names
| Name | triheptanoin |
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| Synonym | More Synonyms |
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TRIHEPTANOIN BiologicalActivity
| Description | Triheptanoin (Propane-1,2,3-triyl triheptanoate) is a synthetic medium-chain triglyceride (MCT) consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone. Triheptanoin can be used for the research of inherited metabolic disorders[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | In long-chain fatty acid oxidation disorders (LC-FAOD), Triheptanoin is used as an anaplerotic compound, acting as a source of calories and fatty acids to bypass the LC-FAOD enzyme deficiencies[1]. Triheptanoin can be used for the research of ataxia-telangiectasia (A-T)[2]. Triheptanoin functions as an anaplerotic agent replenishing tricarboxylic acid (TCA) cycle intermediates by metabolism to heptanoate (C7) and subsequently acetyl-CoA and propionyl-CoA that feed into the TCA cycle to supply energy[2]. Triheptanoin mitigates brain ATP depletion and mitochondrial dysfunction, including respiration and redox balance in a mouse model of Alzheimer's disease, supporting the energy failure hypothesis for that disorder[2]. Triheptanoin (Mice were treated with Triheptanoin (35E%) for 10 days prior to pilocarpine injection to induce status epilepticus) preserved mitochondrial functions in the hippocampal formations of pilocarpine-induced status epilepticus (SE) mice[3]. Animal Model: 7-8 week old male CD1 (35-40 g)[3] Dosage: 35E% oral Triheptanoin was mixed into mouse chow Administration: Given 35E% Triheptanoin treatment 10 days prior to SE induction Result: Preserved mitochondrial functions in SE mice. |
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| References | [1]. Matt Shirley. Triheptanoin: First Approval. Drugs. 2020 Oct;80(15):1595-1600. [2]. A J Yeo, et al. An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Mol Metab. 2021 Dec;54:101354. [3]. Kah Ni Tan, et al. Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. J Neurochem. 2018 Feb;144(4):431-442. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 470.0±12.0 °C at 760 mmHg |
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| Molecular Formula | C24H44O6 |
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| Molecular Weight | 428.603 |
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| Flash Point | 195.5±19.6 °C |
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| Exact Mass | 428.313782 |
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| PSA | 78.90000 |
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| LogP | 7.73 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.457 |
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| InChIKey | PJHKBYALYHRYSK-UHFFFAOYSA-N |
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| SMILES | CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MB2660000
- CHEMICAL NAME :
- Glycerol triheptanoate
- CAS REGISTRY NUMBER :
- 620-67-7
- BEILSTEIN REFERENCE NO. :
- 1807724
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C24-H44-O6
- MOLECULAR WEIGHT :
- 428.68
- WISWESSER LINE NOTATION :
- 6VO1YOV6&1OV6
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940- Volume(issue)/page/year: 40,338,1957
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 38 |
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| HS Code | 2915900090 |
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Customs
| HS Code | 2915900090 |
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| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| Triheptanoin |
| Glycerol-1,2,3-triheptanoate |
| TRIHEPTANION |
| trioenanthoin |
| Propane-1,2,3-triyl triheptanoate |
| trienanthoin |
| propane-1,2,3-triyl trisheptanoate |
| 1,2,3-Propanetriyl triheptanoate |
| glyceryl triheptanoate |
| glycerol trienanthate |
| 1,2,3-tris-heptanoyloxy-propane |
| glyceroltriheptanoate |
| triheptylin |
| tri-heptanoi |
| 1,2,3-Tris-heptanoyloxy-propan |
| Heptanoic acid, 1,2,3-propanetriyl ester |
| triheptanoicglyceride |
| TRIOENANTHIN |
