CAS 22457-55-2|3-Phosphoglyceric acid barium

Introduction：Basic information about CAS 22457-55-2|3-Phosphoglyceric acid barium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name3-Phosphoglyceric acid barium
CAS Number22457-55-2Molecular Weight321.368
Density/Boiling Point536.6ºC at 760mmHg
Molecular FormulaC3H5BaO7PMelting Point/
MSDS/Flash Point278.3ºC

Names

Name3-Phospho-D-glyceric Acid Barium Salt Dihydrate
SynonymMore Synonyms

3-Phosphoglyceric acid barium BiologicalActivity

Description3-Phosphoglyceric acid barium is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid barium is involved in alveolar macrophage epigenetic regulation[1].
Related CatalogResearch Areas >>Metabolic Disease
In Vitro3-Phosphoglyceric acid (400 µM; 24 hours; BMDMs) treatment enhances Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification is also reversed[1]. 3-Phosphoglyceric treatment significantly augmentes gene expression as well as H3K4me3 deposition of Spp1 in IL-4-stimulated macrophages[1]. In yeast, 3-Phosphoglyceric acid acts as a metabolic checkpoint for the formation of a multicomponent enzyme complex including serine metabolic enzymes and pyruvate kinase isoform 2 (PKM2) homologue, which senses both serine metabolism and glycolysis and regulates H3K4 methylation and histone phosphorylation[1]. RT-PCR[1] Cell Line: Bone marrow-derived macrophages (BMDMs) Concentration: 400 µM Incubation Time: 24 hours Result: Enhanced Spp1 transcription in VHL-deficient macrophages, and the reduced H3K4me3 modification was also reversed.
References

[1]. Zhang W, et al. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018 Dec 3;215(12):3180-3193.

Chemical & Physical Properties

Boiling Point536.6ºC at 760mmHg
Molecular FormulaC3H5BaO7P
Molecular Weight321.368
Flash Point278.3ºC
Exact Mass321.882538
PSA246.20000
Vapour Pressure9.37E-14mmHg at 25°C
InChIKeyIAFYHPGYCIOBCG-UHFFFAOYSA-L
SMILESO=C(O)C(O)COP(=O)([O-])[O-].[Ba+2]

Preparation


Synonyms

{2-Hydroxy-3-[(phosphono-κO,O')oxy]propanoato(2-)}barium
3-PHOSPHO-D-GLYCERIC ACID BARIUM SALT
Barium, [2-hydroxy-3-[(phosphono-κO,κO')oxy]propanoato(2-)]-
BARIUM 3-PHOSPHO-D-GLYCERATE DIHYDRATE
barium 3-phospho-d-glycerate
Einecs 245-012-9
3-Phospho-D-glyceric Acid BariuM Salt Dihydrate
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