CAS 155415-08-0|Inogatran

Introduction：Basic information about CAS 155415-08-0|Inogatran, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Inogatran BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Inogatran
CAS Number	155415-08-0	Molecular Weight	438.56400
Density	1.36g/cm3	Boiling Point	/
Molecular Formula	C₂₁H₃₈N₆O₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2-[[(2R)-3-cyclohexyl-1-[(2S)-2-[3-(diaminomethylideneamino)propylcarbamoyl]piperidin-1-yl]-1-oxopropan-2-yl]amino]acetic acid
Synonym	More Synonyms

Inogatran BiologicalActivity

Description	Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>ThrombinResearch Areas >>Cardiovascular Disease
In Vivo	Inogatran (0.075, 0.25, 0.75 mg/kg, i.v.) results in dose-dependent increases in activated partial thromboplastin time (aPTT), thrombin time (TT), and prothrombin time (PT) in a canine electrolytic injury model of venous thrombosis[1]. Inogatran dose-dependently inhibits thrombus formation, which is measured as an increase in time to occlusion (TTO) and a decrease in thrombus weight. Inogatran also improves vena caval blood flow and reduces the overall incidence of thrombotic occlusion in a rat model[2].
References	[1]. Ignasiak DP, et al. Effects of Intravenous Enoxaparin and Intravenous Inogatran in an Electrolytic Injury Model of Venous Thrombosis in the Dog. J Thromb Thrombolysis. 1998 Nov;6(3):199-206. [2]. Chi L, et al. Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: comparison with inogatran. J Thromb Thrombolysis. 2001 Feb;11(1):19-31.

Chemical & Physical Properties

Density	1.36g/cm3
Molecular Formula	C₂₁H₃₈N₆O₄
Molecular Weight	438.56400
Exact Mass	438.29500
PSA	164.13000
LogP	2.73010
Index of Refraction	1.632
InChIKey	CDPROXZBMHOBTQ-SJORKVTESA-N
SMILES	NC(N)=NCCCNC(=O)C1CCCCN1C(=O)C(CC1CCCCC1)NCC(=O)O
Storage condition	2-8℃

Synonyms

N-((1R)-2-Cyclohexyl-1-(((2S)-2-((3-guanidinopropyl)carbamoyl)piperidino)carbonyl)ethyl)glycine

Inogatran [INN]

{[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)AMINO]CARBONYL}PIPERIDINYL)-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]AMINO}ACETIC ACID

IGN

Inogatran

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