CAS 4671-77-6|Butane-1,4-diyldiphosphonic acid

Introduction：Basic information about CAS 4671-77-6|Butane-1,4-diyldiphosphonic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Butane-1,4-diyldiphosphonic acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Butane-1,4-diyldiphosphonic acid
CAS Number	4671-77-6	Molecular Weight	218.08200
Density	/	Boiling Point	544.4ºC at 760 mmHg
Molecular Formula	C₄H₁₂O₆P₂	Melting Point	219-221ºC
MSDS	/	Flash Point	283.1ºC

Names

Name	4-phosphonobutylphosphonic acid
Synonym	More Synonyms

Butane-1,4-diyldiphosphonic acid BiologicalActivity

Description	Butane-1,4-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Boiling Point	544.4ºC at 760 mmHg
Melting Point	219-221ºC
Molecular Formula	C₄H₁₂O₆P₂
Molecular Weight	218.08200
Flash Point	283.1ºC
Exact Mass	218.01100
PSA	134.68000
LogP	0.12200
InChIKey	JKTORXLUQLQJCM-UHFFFAOYSA-N
SMILES	O=P(O)(O)CCCCP(=O)(O)O

Safety Information

Hazard Codes	C
Risk Phrases	R34
Safety Phrases	S25-S36/37/39-S45

Synonyms

1,2-butylenediphosphonic acid

1,4-Diphosphonobutane

1,4-butylene-diphosphonic acid

Butane-1,4-diphosphonic acid

1,4-Butanediphosphonic acid

MFCD01631212

butane-1,4-diyldiphosphonic acid

1,4-butylenediphosphonic avid

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