CAS 60207-90-1|propiconazole
| Common Name | propiconazole | ||
|---|---|---|---|
| CAS Number | 60207-90-1 | Molecular Weight | 342.220 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 480.0±55.0 °C at 760 mmHg |
| Molecular Formula | C15H17Cl2N3O2 | Melting Point | / |
| MSDS | USA | Flash Point | 244.1±31.5 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | propiconazole |
|---|---|
| Synonym | More Synonyms |
propiconazole BiologicalActivity
| Description | Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s = 0.04 µM and >200 µM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s = 0.073 µg/mL and 4.6 µg/mL respectively). Propiconazole increases production of reactive oxygen species (ROS). |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>Fungal |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 480.0±55.0 °C at 760 mmHg |
| Molecular Formula | C15H17Cl2N3O2 |
| Molecular Weight | 342.220 |
| Flash Point | 244.1±31.5 °C |
| Exact Mass | 341.069794 |
| PSA | 49.17000 |
| LogP | 3.88 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.624 |
| InChIKey | STJLVHWMYQXCPB-UHFFFAOYSA-N |
| SMILES | CCCC1COC(Cn2cncn2)(c2ccc(Cl)cc2Cl)O1 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1517 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,508,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,508,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11375 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,118,1992 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 759 ug/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- BFPHA8 Bulletin of the Faculty of Pharmacy (Cairo University). (Faculty of Pharmacy, Cairo Univ., Cairo, Egypt) V.1- 1961/62- Volume(issue)/page/year: 31,459,1993 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H317-H330-H410 |
| Precautionary Statements | P260-P280-P301 + P312 + P330-P304 + P340 + P310-P403 + P233 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn: Harmful;N: Dangerous for the environment;T: Toxic;F: Flammable; |
| Risk Phrases | R22 |
| Safety Phrases | S36/37-S46-S60-S61-S45-S16-S7 |
| RIDADR | UN3082 9/PG 3 |
| RTECS | XZ4620000 |
| HS Code | 2934999025 |
Customs
| HS Code | 2934999025 |
|---|---|
| Summary | 2934999025 5,6-dihydro-3h-imidazo[2,1-c][1,2,4]dithiazole-3-thione。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0% |
Articles27
More Articles| Assessing the potential for algae and macrophytes to degrade crop protection products in aquatic ecosystems. Environ. Toxicol. Chem. 30(3) , 622-31, (2011) Rates of pesticide degradation in aquatic ecosystems often differ between those observed within laboratory studies and field trials. Under field conditions, a number of additional processes may well h... | |
| Analysis of microRNA and gene expression profiling in triazole fungicide-treated HepG2 cell line. Toxicology 303 , 94-8, (2013) MicroRNA (miRNA) plays an important role in various diseases and in cellular and molecular responses to toxicants. In the present study, we investigated differential expression of miRNAs in response t... | |
| Quantitative changes in endogenous DNA adducts correlate with conazole in vivo mutagenicity and tumorigenicity. Mutagenesis 27(5) , 541-9, (2012) The mouse liver tumorigenic conazole fungicides triadimefon and propiconazole have previously been shown to be in vivo mouse liver mutagens in the Big Blue™ transgenic mutation assay when administered... |
Synonyms
| Bumper |
| 1-{[2-(2,4-Dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole |
| 1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]- |
| 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole |
| propiconazole |
| FORDO |
| Juno |
| MFCD00055299 |
| DESME |
| Mycostat P |
| 1-{[(2Ξ,4Ξ)-2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole |
| 1-[2-(2,4-Dichlorophenyl)-4-propyl-[1,3]dioxolan-2-ylmethyl]-1H-[1,2,4]triazole |
| proconazole |
| Orbit |
| Banner |
| EINECS 262-104-4 |
| desmel |
| (2RS,4RS |
| 2RS,4SR)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole |
| radar |
| Dadar |
| Tilt |
| Wocosin |
| TRUST |
| Wocosin 50TK |
