CAS 521-61-9|Physcion
| Common Name | Physcion | ||
|---|---|---|---|
| CAS Number | 521-61-9 | Molecular Weight | 284.26 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 560.5±50.0 °C at 760 mmHg |
| Molecular Formula | C16H12O5 | Melting Point | 196-206°C |
| MSDS | ChineseUSA | Flash Point | 215.4±23.6 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione |
|---|---|
| Synonym | More Synonyms |
Physcion BiologicalActivity
| Description | Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| Target | IC50: 38.5 μM (6-phosphogluconate dehydrogenase)[1] Kd: 26.0 μM (6-phosphogluconate dehydrogenase)[1] |
| References | [1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. [2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 560.5±50.0 °C at 760 mmHg |
| Melting Point | 196-206°C |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.26 |
| Flash Point | 215.4±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 83.83000 |
| LogP | 5.20 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.678 |
| InChIKey | FFWOKTFYGVYKIR-UHFFFAOYSA-N |
| SMILES | COc1cc(O)c2c(c1)C(=O)c1cc(C)cc(O)c1C2=O |
| Storage condition | -20°C Freezer, Under Inert Atmosphere |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,1342,1979
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 27,1342,1979
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | CB6720000 |
| HS Code | 2914699010 |
Customs
| HS Code | 2914690090 |
|---|---|
| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
Articles40
More Articles| Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 88-93, (2015) Most herbal medicines are prescribed in combination based on the theory of TCM to obtain synergistic effects or diminish the possible adverse reactions. Compatibility refers to the combination of two ... | |
| Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives. Bioorg. Med. Chem. Lett. 18 , 4106-9, (2008) As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin deriva... | |
| Activity-guided chemo toxic profiling of Cassia occidentalis (CO) seeds: detection of toxic compounds in body fluids of CO-exposed patients and experimental rats. Chem. Res. Toxicol. 28 , 1120-32, (2015) Our prior studies have shown an association between the deaths of children and consumption of Cassia occidentalis (CO) seeds. However, the chemicals responsible for the CO poisoning are not known. The... |
Synonyms
| 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione |
| Emodin 3-methyl ether |
| EINECS 208-315-7 |
| MFCD00017374 |
| Emodin monomethyl ether |
| 9,10-Anthracenedione, 1,8-dihydroxy-3-methoxy-6-methyl- |
| Parietin |
| Methoxyemodin |
| 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione |
| Emodin-3-methyl ether |
| Rheochrysidin |
| physicion |
| phycion |
| 1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone |
| Physcion |
| 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone,Emodin-3-methyl ether |
| 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone |
| 1,8-dihydroxy-5-methyl-3-methoxy-9,10-anthraquinone |
| Physcione |
