CAS 76455-48-6|4-Bromo-antibiotic

Introduction：Basic information about CAS 76455-48-6|4-Bromo-antibiotic, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 4-Bromo-antibiotic BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles27

Common Name	4-Bromo-antibiotic
CAS Number	76455-48-6	Molecular Weight	602.51700
Density	1.43g/cm3	Boiling Point	735.4ºC at 760 mmHg
Molecular Formula	C₂₉H₃₆BrN₃O₆	Melting Point	/
MSDS	ChineseUSA	Flash Point	398.5ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	4-bromo-a23187

4-Bromo-antibiotic BiologicalActivity

Description	4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187，a calcium modulator, induces apoptosis in different cells, including HL-60 cells[1].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer
References	[1]. Zhu WH, et al. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995;57(23):2091-9.

Chemical & Physical Properties

Density	1.43g/cm3
Boiling Point	735.4ºC at 760 mmHg
Molecular Formula	C₂₉H₃₆BrN₃O₆
Molecular Weight	602.51700
Flash Point	398.5ºC
Exact Mass	601.17900
PSA	126.68000
LogP	6.36530
Index of Refraction	1.628
InChIKey	LDXQFZZGVTWFCF-FHYGWRBKSA-N
SMILES	CNc1c(Br)cc2oc(CC3OC4(CCC3C)OC(C(C)C(=O)c3ccc[nH]3)C(C)CC4C)nc2c1C(=O)O
Storage condition	-20°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Articles27

Mast cell histamine-induced calcium transients in cultured human peritoneal mesothelial cells.

Perit. Dial. Int. 18(6) , 626-36, (1998)

Peritoneal inflammation results from a complex interplay of events initiated by macrophage activity in response to infection, with the stimulation of mesothelial cell cytokine release amplifying the r...

Activity-dependent development of calcium regulation in growing motor axons.

J. Neurosci. 18(13) , 4966-72, (1998)

In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2...

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.

J. Biol. Chem. 284(29) , 19744-53, (2009)

The Na/H exchanger 3 (NHE3) and the Cl/HCO(3) exchanger down-regulated in adenoma (DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca(2+)(i) inhibits NHE3 through mechanis...

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