CAS 50-32-8|Benzo(a)pyrene
Introduction：Basic information about CAS 50-32-8|Benzo(a)pyrene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benzo(a)pyrene | ||
|---|---|---|---|
| CAS Number | 50-32-8 | Molecular Weight | 252.309 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 495.0±0.0 °C at 760 mmHg |
| Molecular Formula | C20H12 | Melting Point | 177-180°C |
| MSDS | ChineseUSA | Flash Point | 228.6±13.7 °C |
| Symbol | GHS07, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | benzo[a]pyrene |
|---|---|
| Synonym | More Synonyms |
Benzo(a)pyrene BiologicalActivity
| Description | Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cancer |
| In Vivo | Statistically significant decrease is observed at 7 weeks in females receiving 1.0 mg Benzo[a]pyrene (B[a]P) compare with the vehicle group. As lung tumorigenesis induced by Benzo[a]pyrene is dose dependent in female A/J mice. The incidence of hyperplasia values in females treating with 0.25, 0.50, and 1.0 mg Benzo[a]pyrene are significantly higher than in the vehicle-treated group. The incidence of adenoma in females receiving 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of hyperplasia in females receiving 0.50 or 1.0 mg Benzo[a]pyrene is significantly higher than in the vehicle group. The multiplicity of adenoma in the group treated with 1.0 mg is also significantly higher than in the vehicle group. The incidences of hyperplasia and adenoma in female A/J mice are significantly increased by Benzo[a]pyrene in a dose-dependent manner[1]. Benzo[a]pyrene induces an average of 9.38±1.75 tumors with an average tumor load of 19.53±3.81 mm3 (P<0.05 compare to control). Benzo[a]pyrene administration significantly (P<0.05) decreases cAMP levels in tumors with adjacent lung tissues. The expression level of PDE4D gene is also increased by Benzo[a]pyrene administration[2]. |
| Animal Admin | Female A/J mice are randomized into eight groups (n=8): (i) control; (ii)Benzo[a]pyrene (B(a)P)+vehicle (methocel); (iii) Benzo[a]pyrene+roflumilast 1 mg/kg; (iv) Benzo[a]pyrene+roflumilast 5 mg/kg; (v) Benzo[a]pyrene+aerozolie phosphate-buffer saline (PBS); (vi) Benzo[a]pyrene+aerosolize budesonide 2.25 mg/mL; (vii) Benzo[a]pyrene+aerosolized budesonide 2.25 mg/mL+roflumilast 1 mg/kg; and (viii) Benzo[a]pyrene+aerosolize budesonide 2.25 mg/mL+roflumilast 5 mg/kg groups. A single dose of Benzo[a]pyrene in corn oil is given intraperitoneally once at 100 mg/kg body weight. Roflumilast (1 or 5 mg/kg) is started 2 weeks after Benzo[a]pyrene. It is continued for 26 weeks (3 days/week) via oral gavage. Mice in the Benzo[a]pyrene+vehicle group are treated with an equal volume of methocel as solvent control. Aerosolizing budesonide is administrated by inhaling route as an aerosol at a dose of 2.25 mg/mL for 2 min per application at 2 weeks after Benzo[a]pyrene. It is continued for 26 weeks (5 days/week). PBS is also used as solvent control by inhaling route after Benzo[a]pyrene administration in the Benzo[a]pyrene+PBS group. Mice are killed at 28 weeks after exposure to Benzo[a]pyrene. Their lungs are excised and stored at -70 °C[2]. |
| References | [1]. Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30(3): 209–216. [2]. Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5;812:189- |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 495.0±0.0 °C at 760 mmHg |
| Melting Point | 177-180°C |
| Molecular Formula | C20H12 |
| Molecular Weight | 252.309 |
| Flash Point | 228.6±13.7 °C |
| Exact Mass | 252.093903 |
| LogP | 6.40 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.887 |
| InChIKey | FMMWHPNWAFZXNH-UHFFFAOYSA-N |
| SMILES | c1ccc2c(c1)cc1ccc3cccc4ccc2c1c34 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Safety Information
| Symbol | GHS07, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H340-H350-H360FD-H410 |
| Supplemental HS | Repeated exposure may cause skin dryness or cracking. |
| Precautionary Statements | P201-P273-P280-P308 + P313-P333 + P313-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | F:Flammable;T:Toxic; |
| Risk Phrases | R45;R11;R38;R50/53;R65;R67 |
| Safety Phrases | S45-S53-S61-S60-S26-S62 |
| RIDADR | 2811 |
| RTECS | DJ3675000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 2902909090 |
Customs
| HS Code | 2902909090 |
|---|---|
| Summary | 2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0% |
Articles167
More Articles| Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells. Toxicol. Sci. 139(2) , 338-49, (2014) Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex m... | |
| Carvacrol and rosemary essential oil manifest cytotoxic, DNA-protective and pro-apoptotic effect having no effect on DNA repair. Neoplasma 61(6) , 690-9, (2014) For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effe... | |
| BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors. Environ. Sci. Pollut. Res. Int. 22 , 16393-404, (2015) Assessment of exposure and effect of fish to pharmaceuticals that contaminate aquatic environment is a current major issue in ecotoxicology and there is a need to develop specific biological marker to... |
Synonyms
| UNII-3417WMA06D |
| Benzo[a]pyrene (Ames grade) |
| Benzo[A]Pyrene |
| Benzo(d,e,f)chrysene |
| Benzo(a)pyrene |
| Benzo[a]pyren |
| benzo[1,2,5]thiadiazole-4-sulfonyl chloride |
| 2,1,3-benzothiadiazol-4-sulfonyl chloride |
| 3,4-Benzpyrene |
| 3,4-Benz(a)pyrene |
| 4,5-BENZPYRENE |
| 2,1,3-Benzothiadiazole,4-chlorosulfonyl |
| 3,4-benzopyrene |
| 2,1,3-benzothiadiazole-4-sulphonyl chloride |
| 1,2-Benzpyrene (VAN) |
| Benzo[pqr]tetraphene |
| Benzopyrene |
| 4-Chlorosulfonyl-2,1,3-benzothiadiazole |
| 2,1,3-benzothiadiazole-4-sulfonylchloride |
| 3,4-Benzo(a)pyrene |
| Benzo-2,1,3-thiadiazole-4-sulphonyl chloride |
| Benzo[c][1,2,5]thiadiazole-4-sulfonyl chloride |
| EINECS 200-028-5 |
| benz[a]pyrene |
| benzo[2,1,3]thiadiazole-4-sulfonyl chloride |
| 6,7-Benzopyrene |
| MFCD00003602 |
| 1,2-Benzpyrene |
