CAS 7299-11-8|Psoromic Acid
Introduction：Basic information about CAS 7299-11-8|Psoromic Acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Psoromic Acid | ||
|---|---|---|---|
| CAS Number | 7299-11-8 | Molecular Weight | 358.30 |
| Density | 1.483 g/cm3 | Boiling Point | 641.7ºC at 760 mmHg |
| Molecular Formula | C18H14O8 | Melting Point | / |
| MSDS | / | Flash Point | 237ºC |
Names
| Name | 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
Psoromic Acid BiologicalActivity
| Description | Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
| Target | IC50: 1.3 µM (RabGGTase)[1] |
| References | [1]. Deraeve C, et al. Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc. 2012 May 2;134(17):7384-91. [2]. Behera BC, et al. Antioxidative and cardiovascular-protective activities of metabolite usnic acid and psoromic acid produced by lichen species Usnea complanata under submerged fermentation. Pharm Biol. 2012 Aug;50(8):968-79. |
Chemical & Physical Properties
| Density | 1.483 g/cm3 |
|---|---|
| Boiling Point | 641.7ºC at 760 mmHg |
| Molecular Formula | C18H14O8 |
| Molecular Weight | 358.30 |
| Flash Point | 237ºC |
| Exact Mass | 358.06900 |
| PSA | 119.36000 |
| LogP | 2.85320 |
| Index of Refraction | 1.658 |
| InChIKey | FUCWJKJZOHOLEO-UHFFFAOYSA-N |
| SMILES | COc1cc(C(=O)O)c2c(c1C)OC(=O)c1c(C)cc(O)c(C=O)c1O2 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982
Synonyms
| Parellic acid |
| Psoromsaeure |
| psoromic acid |
