CAS 90719-30-5|Locostatin

Introduction：Basic information about CAS 90719-30-5|Locostatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Locostatin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Locostatin
CAS Number	90719-30-5	Molecular Weight	197.23100
Density	1.205 g/cm3	Boiling Point	351ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅NO₃	Melting Point	84-88ºC(lit.)
MSDS	USA	Flash Point	166.1ºC

Names

Name	(n-crotonyl)-(4s)-isopropyl-2-oxazolidinone
Synonym	More Synonyms

Locostatin BiologicalActivity

Description	Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
Target	RKIP[3]
In Vitro	Locostatin (200 µM；37 °C；6 小时) 破坏 RKIP 与 Raf-1 和 GRK2 的相互作用[1]。 Locostatin (50 µM；0-48 小时) 抑制 MDCK 细胞的增殖和迁移[2]。 Cell Proliferation Assay[2] Cell Line: MDCK cells Concentration: 50 µM Incubation Time: 0-48 h Result: Inhibited cell proliferation and sheet migration.
In Vivo	Locostatin (0.5 mg/kg；腹腔注射；每天一次，连续 7 天) 加重硫代乙酰胺 (HY-Y0698) 诱导的小鼠急性肝衰竭[3]。 Animal Model: 6 weeks, 18-22 g, male ICR mice (TAA model; injected intraperitoneally with 300 mg/kg TAA once a day for 2 days)[3] Dosage: 0.5 mg/kg Administration: I.p.; once a day for 7 days Result: Decreased the expression of RKIP, led to more severe damage, such as steatosis and hepatic lesions, increased the production of ROS in the liver and TNF-α, IL-6 and IL-1β in the sera of mice with acute liver injury, inhibitd Nrf2 and HO-1 expression in the livers of mice, induced NF-κB activation in the livers of mice,increased the phosphorylation of JNK, p38 and ERK in liver tissues.
References	[1]. Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. [2]. Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. [3]. Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998.

Chemical & Physical Properties

Density	1.205 g/cm3
Boiling Point	351ºC at 760 mmHg
Melting Point	84-88ºC(lit.)
Molecular Formula	C₁₀H₁₅NO₃
Molecular Weight	197.23100
Flash Point	166.1ºC
Exact Mass	197.10500
PSA	46.61000
LogP	1.29870
Appearance of Characters	white to off-white
InChIKey	UTZAFVPPWUIPBH-QSLRECBCSA-N
SMILES	CC=CC(=O)N1C(=O)OCC1Cc1ccccc1
Storage condition	2-8°C
Water Solubility	DMSO: ≥30mg/mL

Safety Information

Risk Phrases	24/25
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29349990

Synonyms

(4S)-N-Crotonyl-4-benzyl-2-oxazolidinone

(R)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE

(S,E)-3-(but-2'-enoyl)-4-benzyloxazolidin-2-one

(S)-3-((E)-but-2-enoyl)-4-benzyloxazolidin-2-one

4-(S)-benzyl-((E)-2'-butenoyl)-1,3-oxazolidin-2-one

(4S)-3-((E)-2-butenoyl)-4-(phenylmethyl)-2-oxazolidinone

(4S)-3-[(E)-BUT-2-ENOYL]-4-BENZYL-2-OXAZOLIDINONE

(4S)-N-[(2E)-but-2-enoyl]-4-phenylmethyl-1,3-oxazolidin-2-one

(N-CROTONYL)-(4S)-BENZYL-2-OXAZOLIDINONE

UIC-1005

(S,E)-4-benzyl-3-(but-2-enoyl)oxazolidin-2-one

MFCD00278769

(S)-3-((E)-but-2-enoyl)-4-benzyloxazolidinone

(N-Crotonyl)-(R)-4-benzyl-2-oxazolidinone

(S)-(+)-4-BENZYL-3-CROTONYL-2-OXAZOLIDINONE

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