CAS 485-63-2|3',4',7-trihydroxy isoflavone

Introduction：Basic information about CAS 485-63-2|3',4',7-trihydroxy isoflavone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 3',4',7-trihydroxy isoflavone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	3',4',7-trihydroxy isoflavone
CAS Number	485-63-2	Molecular Weight	270.24
Density	1.5±0.1 g/cm3	Boiling Point	572.8±50.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₀O₅	Melting Point	280-282°C
MSDS	/	Flash Point	224.0±23.6 °C

Names

Name	3',4',7-trihydroxyisoflavone
Synonym	More Synonyms

3',4',7-trihydroxy isoflavone BiologicalActivity

Description	7,3',4'-Trihydroxyisoflavone, a major metabolite of Daidzein, is an ATP-competitive inhibitor of Cot (Tpl2/MAP3K8) and MKK4. 7,3',4'-Trihydroxyisoflavone has anticancer, anti-angiogenic, chemoprotective, and free radical scavenging activities[1][2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>MAPK/ERK Pathway >>MAP3K
In Vitro	7,3',4'-Trihydroxyisoflavone triggers cell cycle arrest at the G1 phase and displays an anti-proliferative effect against EGF receptor-positive skin cancer[1]. 7,3',4'-Trihydroxyisoflavone also significantly inhibits UVB-induced COX-2 expression by suppressing the NF-B transcription activity in mouse skin epidermal JB6 P+ cells[1].
In Vivo	In a mouse skin tumorigenesis model, 7,3',4'-Trihydroxyisoflavone strongly suppresses the incidence, multiplicity, and volume of UVB-induced mouse skin tumors. Consistent with the tumor data, 7,3',4'-Trihydroxyisoflavone clearly attenuates UVB-induced COX-2 expression in hairless mouse skin[2].
References	[1]. Yu-Li Lo, et al. 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. Toxicology. 2012 Dec 16;302(2-3):221-32. [2]. Dong Eun Lee, et al. 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. J Biol Chem. 2011 Apr 22;286(16):14246-56.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	572.8±50.0 °C at 760 mmHg
Melting Point	280-282°C
Molecular Formula	C₁₅H₁₀O₅
Molecular Weight	270.24
Flash Point	224.0±23.6 °C
Exact Mass	270.052826
PSA	90.90000
LogP	2.58
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.732
InChIKey	DDKGKOOLFLYZDL-UHFFFAOYSA-N
SMILES	O=c1c(-c2ccc(O)c(O)c2)coc2cc(O)ccc12
Storage condition	-20°C Freezer
Stability	Store in Freezer

Safety Information

Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
WGK Germany	3

Synonyms

7,3',4'-THIF

3-(3,4-Dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one

3',4',7-Trihydroxyisoflavone

3`,4`,7-Trihydroxyisoflavone

4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-7-hydroxy-

3l5r

MFCD00143002

3-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-on

3',4',7-trihydroxy isoflavone

3'-Hydroxydaidzein

3-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one

3-(3,4-dihydroxy-phenyl)-7-hydroxy-chromen-4-one

7,3',4'-Trihydroxyisoflavone

7-Hydroxy-3-(3,4-dihydroxyphenyl)-4H-chromen-4-one

4H-1-Benzopyran-4-one,3-(3,4-dihydroxyphenyl)-7-hydroxy

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