CAS 480-37-5|Pinocembrin-7-methyl ether
| Common Name | Pinocembrin-7-methyl ether | ||
|---|---|---|---|
| CAS Number | 480-37-5 | Molecular Weight | 270.280 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 494.9±45.0 °C at 760 mmHg |
| Molecular Formula | C16H14O4 | Melting Point | 100ºC |
| MSDS | ChineseUSA | Flash Point | 188.8±22.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | pinostrobin |
|---|---|
| Synonym | More Synonyms |
Pinocembrin-7-methyl ether BiologicalActivity
| Description | Pinostrobin is a flavonoid can be found in many plants, and has anti-oxidant, anti-inflammatory, anti-cancer and neuroprotective properties. Pinostrobin is a potent PCSK9 inhibitor and inhibits the catalytic activity of PCSK9. Pinostrobin is a promising agent for cholesterol regulation and lipid management[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Inflammation/Immunology |
| Target | IC50: PCSK9[1] |
| References | [1]. Gao WY, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells.J Agric Food Chem. 2018 Jun 20;66(24):6083-6093. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 494.9±45.0 °C at 760 mmHg |
| Melting Point | 100ºC |
| Molecular Formula | C16H14O4 |
| Molecular Weight | 270.280 |
| Flash Point | 188.8±22.2 °C |
| Exact Mass | 270.089203 |
| PSA | 55.76000 |
| LogP | 4.11 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.612 |
| InChIKey | ORJDDOBAOGKRJV-AWEZNQCLSA-N |
| SMILES | COc1cc(O)c2c(c1)OC(c1ccccc1)CC2=O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles11
More Articles| Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria). Phytother Res. 29(1) , 48-58, (2015) Stingless bees accumulate deposits of plant resins that are mixed with beeswax to produce propolis. Previous studies have reported anti-microbial constituents of stingless bee (Tetragonula carbonaria)... | |
| Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells. J. Nat. Prod. 73 , 623-7, (2010) Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7''R)-8-[1-(4'-hydroxy-3'-methoxyphen... | |
| Cytotoxic flavonoids from the leaves of Cryptocarya chinensis. J. Nat. Prod. 73 , 1470-5, (2010) Bioassay-guided fractionation led to the isolation of six new tetrahydroflavanones, cryptochinones A-F (1-6), from the neutral CHCl(3) fraction of Cryptocarya chinensis leaves, together with 14 known ... |
Synonyms
| Dihydrotectochrysin |
| 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (S)- |
| Pinostrobin |
| 2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one |
| (S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one |
| Pistrobin |
| Pinocembrin-7-methyl ether |
| 5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one |
| (2S)-5-Hydroxy-7-methoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one |
| 2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one |
| Pinostobin |
| 4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (2S)- |
