Introduction：Basic information about CAS 607737-87-1|A 77-01, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | A 77-01 |
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| CAS Number | 607737-87-1 | Molecular Weight | 286.33100 |
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| Density | 1.254g/cm3 | Boiling Point | 481.63ºC at 760 mmHg |
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| Molecular Formula | C18H14N4 | Melting Point | / |
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| MSDS | / | Flash Point | 256.391ºC |
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Names
| Name | 4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline |
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| Synonym | More Synonyms |
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A 77-01 BiologicalActivity
| Description | A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1]Target: ALK5A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01. |
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| Related Catalog | Signaling Pathways >>TGF-beta/Smad >>TGF-β ReceptorResearch Areas >>Cancer |
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| References | [1]. Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800. |
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Chemical & Physical Properties
| Density | 1.254g/cm3 |
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| Boiling Point | 481.63ºC at 760 mmHg |
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| Molecular Formula | C18H14N4 |
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| Molecular Weight | 286.33100 |
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| Flash Point | 256.391ºC |
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| Exact Mass | 286.12200 |
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| PSA | 54.46000 |
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| LogP | 3.99530 |
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| Index of Refraction | 1.685 |
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| InChIKey | KJTYZDORHCDZPS-UHFFFAOYSA-N |
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| SMILES | Cc1cccc(-c2[nH]ncc2-c2ccnc3ccccc23)n1 |
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| Storage condition | 2-8℃ |
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Synonyms
| 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinolone |
| A 77-01 |
