Introduction：Basic information about CAS 50-85-1|2-Hydroxy-4-methylbenzoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Methylsalicylic acid is a salicylic acid. 4-Methylsalicylic acid derivative is a selective tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) inhibitor[1].
Related Catalog
Signaling Pathways >>Apoptosis >>IAPResearch Areas >>Inflammation/Immunology
References
[1]. Mumtaz A, et al. Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies. Bioorg Chem. 2020 Aug;101:103996.
Chemical & Physical Properties
Density
1.3±0.1 g/cm3
Boiling Point
315.2±30.0 °C at 760 mmHg
Melting Point
173-177 °C(lit.)
Molecular Formula
C8H8O3
Molecular Weight
152.147
Flash Point
158.6±21.1 °C
Exact Mass
152.047348
PSA
57.53000
LogP
2.52
Vapour Pressure
0.0±0.7 mmHg at 25°C
Index of Refraction
1.600
InChIKey
NJESAXZANHETJV-UHFFFAOYSA-N
SMILES
Cc1ccc(C(=O)O)c(O)c1
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
GP3920100
CHEMICAL NAME :
2,4-Cresotic acid
CAS REGISTRY NUMBER :
50-85-1
BEILSTEIN REFERENCE NO. :
2208140
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H8-O3
MOLECULAR WEIGHT :
152.16
WISWESSER LINE NOTATION :
QVR BQ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Guang Pu Xue Yu Guang Pu Fen Xi 30(1) , 170-3, (2010)
New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)2 Ir(LX) (ppy==2-phenylpyridine, LX==Sal (salicylic acid), Msal (4-methylsalicylic acid), FSal(4-trifluoro methyl salicylic acid)) was ...
Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.
Biochem. Pharmacol. 52 , 1643-1646, (1996)
Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate. Salicylic acid, 4-methylsali...
