CAS 94-41-7|1,3-Diphenyl-2-propen-1-one
Introduction：Basic information about CAS 94-41-7|1,3-Diphenyl-2-propen-1-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,3-Diphenyl-2-propen-1-one | ||
|---|---|---|---|
| CAS Number | 94-41-7 | Molecular Weight | 208.25500 |
| Density | / | Boiling Point | 208 °C25 mm Hg(lit.) |
| Molecular Formula | C15H12O | Melting Point | 55-59 °C |
| MSDS | ChineseUSA | Flash Point | >230 °F |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | chalcone |
|---|---|
| Synonym | More Synonyms |
1,3-Diphenyl-2-propen-1-one BiologicalActivity
| Description | Chalcone is isolated from Glycyrrhizae inflata and used to synthesize chalcone derivatives. Chalcone derivatives possess varied biological and pharmacological activity, including anti-inflammatory, antioxidative, antibacterial, anticancer, and anti-parasitic activities[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Chalcone derivatives are synthesized by Claisen-Shimidt base-catalyzed condensation of appropriate aromatic ketones or substituted aromatic ketones with benzaldehydes or substituted benzaldehydes[1]. |
| References | [1]. Shailendra Mandge,et al. Synthesis and Characterization of Some Chalcone Derivatives. Trends in Applied Sciences Research Volume 2 (1): 52-56, 2007 |
Chemical & Physical Properties
| Boiling Point | 208 °C25 mm Hg(lit.) |
|---|---|
| Melting Point | 55-59 °C |
| Molecular Formula | C15H12O |
| Molecular Weight | 208.25500 |
| Flash Point | >230 °F |
| Exact Mass | 208.08900 |
| PSA | 17.07000 |
| LogP | 3.58270 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 681 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 250 units/L
- REFERENCE :
- ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 35,629,1964
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 250 units/L
- REFERENCE :
- ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 35,629,1964
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn,Xi |
| Risk Phrases | R22:Harmful if swallowed. R36/37:Irritating to eyes and respiratory system . |
| Safety Phrases | S22-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UD5576750 |
| HS Code | 2914399090 |
Customs
| HS Code | 2914399090 |
|---|---|
| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
Articles37
More Articles| Antimycobacterial and anti-inflammatory activities of substituted chalcones focusing on an anti-tuberculosis dual treatment approach. Molecules 20 , 8072-93, (2015) Tuberculosis (TB) remains a serious public health problem aggravated by the emergence of M. tuberculosis (Mtb) strains resistant to multiple drugs (MDR). Delay in TB treatment, common in the MDR-TB ca... | |
| Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations. Molecules 17(11) , 12925-37, (2012) A high performance liquid chromatographic (HPLC) method with diode array detection (DAD) was established for simultaneous determination of seven main bioactive components in San-ao decoction and its s... | |
| Development of a stability-indicating LC method for determination of a synthetic chalcone derivative in a nanoemulsion dosage form and identification of the main photodegradation product by LC-MS. J. Pharm. Biomed. Anal. 70 , 652-6, (2012) This study aimed to develop and validate a stability indicating LC for the determination of 5-(2-benzoylethenyl)-N-benzyl-2 methoxybenzenesulfonamide (SCD - a synthetic chalcone derivative), and evalu... |
Synonyms
| EINECS 202-330-2 |
| BENZALACETOPHENONE |
| benzylidene acetophenone |
| CHALKONE |
| MFCD00003082 |
| Cinnamophenone |
| CHALCONE |
| PhCOCH=CHPh |
| styrylphenylketone |
