CAS 760-78-1|DL-Norvaline
| Common Name | DL-Norvaline | ||
|---|---|---|---|
| CAS Number | 760-78-1 | Molecular Weight | 117.146 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 222.9±23.0 °C at 760 mmHg |
| Molecular Formula | C5H11NO2 | Melting Point | ≥300 °C (dec.) |
| MSDS | USA | Flash Point | 88.6±22.6 °C |
Names
| Name | 2-aminopentanoic acid |
|---|---|
| Synonym | More Synonyms |
DL-Norvaline BiologicalActivity
| Description | DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>ArginaseResearch Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2]. |
| Cell Assay | A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1]. |
| References | [1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50. [2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 222.9±23.0 °C at 760 mmHg |
| Melting Point | ≥300 °C (dec.) |
| Molecular Formula | C5H11NO2 |
| Molecular Weight | 117.146 |
| Flash Point | 88.6±22.6 °C |
| Exact Mass | 117.078979 |
| PSA | 63.32000 |
| LogP | 0.38 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.464 |
| InChIKey | SNDPXSYFESPGGJ-UHFFFAOYSA-N |
| SMILES | CCCC(N)C(=O)O |
| Storage condition | Store at RT. |
| Water Solubility | 1 g/10 mL (18 ºC) |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 29224995 |
Customs
| HS Code | 29224995 |
|---|
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Synonyms
| DL-NORVALINE |
| α-DL-Aminopentanoic acid |
| DL-2-Aminovaleric Acid |
| 2-Aminovaleric acid |
| MFCD00064420 |
| DL-norVal-OH |
| DL-2-Aminopentanoic acid |
| (±)-2-Aminopentanoic acid |
| H-DL-Nva-OH |
| rac-norvaline |
| a-Aminovaleric Acid |
| 2-Aminopentanoic acid |
| EINECS 212-082-7 |
| APE |
| DL-α-Aminovaleric acid |
| Norvaline |
| Norvaline, DL- |
| NVA |
| UNII:V639KTF2SZ |
| Norvaline (VAN) |
| (±)-Norvaline |
| aminovaleric acid |
