Introduction：Basic information about CAS 29031-19-4|2-Amino-2-deoxy-D-glucose sulfate (1:1), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Amino-2-deoxy-D-glucose sulfate (1:1) |
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| CAS Number | 29031-19-4 | Molecular Weight | 277.250 |
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| Density | 1.563g/cm3 | Boiling Point | 449.9ºC at 760mmHg |
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| Molecular Formula | C6H13NO5.xH2O4S | Melting Point | 176°C |
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| MSDS | / | Flash Point | 225.9ºC |
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Names
| Name | D-Glucosamine Sulfate Salt |
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| Synonym | More Synonyms |
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2-Amino-2-deoxy-D-glucose sulfate (1:1) BiologicalActivity
| Description | Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>Autophagy |
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| Target | Human Endogenous Metabolite |
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| In Vitro | Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity[2]. Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3]. Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4]. |
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| References | [1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7. [2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. [3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706. [4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. |
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Chemical & Physical Properties
| Density | 1.563g/cm3 |
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| Boiling Point | 449.9ºC at 760mmHg |
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| Melting Point | 176°C |
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| Molecular Formula | C6H13NO5.xH2O4S |
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| Molecular Weight | 277.250 |
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| Flash Point | 225.9ºC |
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| Exact Mass | 277.046753 |
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| PSA | 206.99000 |
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| Vapour Pressure | 5.53E-10mmHg at 25°C |
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| InChIKey | FGNPLIQZJCYWLE-BTVCFUMJSA-L |
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| SMILES | NC(C=O)C(O)C(O)C(O)CO.O=S(=O)([O-])[O-] |
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| Storage condition | -20?C Freezer |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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| RTECS | AU7417000 |
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| HS Code | 2932999099 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| D-Glucose, 2-amino-2-deoxy-, sulfate (1:1) |
| D-Glucosamine sulfate |
| 2-Amino-2-deoxy-D-glucose sulfate (1:1) |
| EINECS 249-379-6 |
| MFCD00151175 |
