Introduction：Basic information about CAS 116371-67-6|Gemcitabine Monophosphate Formate Salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Gemcitabine Monophosphate Formate Salt |
|---|
| CAS Number | 116371-67-6 | Molecular Weight | 343.17800 |
|---|
| Density | 2.09 | Boiling Point | 618.3ºC at 760 mmHg |
|---|
| Molecular Formula | C9H12F2N3O7P | Melting Point | 151-153 °C |
|---|
| MSDS | / | Flash Point | 327.736ºC |
|---|
Names
| Name | [(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate,formic acid |
|---|
| Synonym | More Synonyms |
|---|
Gemcitabine Monophosphate Formate Salt BiologicalActivity
| Description | Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate shows synergistic anti-cancer effects[1][2]. |
|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
|---|
| References | [1]. Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. [2]. Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. |
|---|
Chemical & Physical Properties
| Density | 2.09 |
|---|
| Boiling Point | 618.3ºC at 760 mmHg |
|---|
| Melting Point | 151-153 °C |
|---|
| Molecular Formula | C9H12F2N3O7P |
|---|
| Molecular Weight | 343.17800 |
|---|
| Flash Point | 327.736ºC |
|---|
| Exact Mass | 343.03800 |
|---|
| PSA | 166.94000 |
|---|
| Index of Refraction | 1.681 |
|---|
| InChIKey | KNTREFQOVSMROS-QPPQHZFASA-N |
|---|
| SMILES | Nc1ccn(C2OC(COP(=O)(O)O)C(O)C2(F)F)c(=O)n1 |
|---|
Synonyms
| gemcitabine 5'-monophosphate |
| 2'-deoxy-2',2'-difluorocytidine 5-monophosphate |
| 2'-Deoxy-2',2'-difluoro-5'-cytidylic Acid Formate |
| Gemcitabine Monophosphate Formate Salt |
| Gemcitabine monophosphate |
