Introduction：Basic information about CAS 509088-69-1|KRP-203 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | KRP-203 hydrochloride |
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| CAS Number | 509088-69-1 | Molecular Weight | 480.447 |
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| Density | / | Boiling Point | 657.1ºC at 760 mmHg |
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| Molecular Formula | C24H27Cl2NO3S | Melting Point | 199-200ºC (DEC.) |
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| MSDS | / | Flash Point | 351.2ºC |
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Names
| Name | 2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol,hydrochloride |
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| Synonym | More Synonyms |
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KRP-203 hydrochloride BiologicalActivity
| Description | Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2]. |
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| Target | S1PR1[1] |
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| In Vivo | Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R−/− Mice[1]. Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2]. Animal Model: Inbred male DA (MHC haplotype: RT1a) rats[2] Dosage: 0.1 and 1 mg/kg Administration: Orally; daily; for 100 days Result: Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts. |
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| References | [1]. Potì F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12. [2]. Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10. |
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Chemical & Physical Properties
| Boiling Point | 657.1ºC at 760 mmHg |
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| Melting Point | 199-200ºC (DEC.) |
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| Molecular Formula | C24H27Cl2NO3S |
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| Molecular Weight | 480.447 |
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| Flash Point | 351.2ºC |
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| Exact Mass | 479.108856 |
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| PSA | 101.01000 |
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| LogP | 6.18720 |
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| InChIKey | MYIFLDFUXIHOCJ-UHFFFAOYSA-N |
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| SMILES | Cl.NC(CO)(CO)CCc1ccc(Sc2cccc(OCc3ccccc3)c2)cc1Cl |
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Synonyms
| 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1) |
| KRP-203 hydrochloride |
| 2-Amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]-1,3-propanediol hydrochloride (1:1) |
| KRP-203 |
| 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride |
